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  陈俐娟

【简历】

 陈俐娟 ,42岁,女,教授/博士生导师,肿瘤生物研究室副主任,中国医药生物技术协会,纳米生物专业委员会理事;四川大学学报医学版编委, 英国 University of Wales Swansea 大学博士毕业,主要从事天然及小分子抗肿瘤、抗炎活性成分筛选、合成及相关新药研发;新型缓释药物载体材料的应用;液相色谱与质谱技术在药物代谢及药物动力学中的研究。近年来 已发表论文 115 篇, SCI 收录论文 95 篇,其中以第一作者 / 通讯作者在国际杂志上发表 SCI 收录论文 60 篇 , 主要国际论文被他人在 30 多种国际其它杂志上多次引用 达237次.主要代表作发表在 Mass Spectrom Rev ( IF:11.5 ), J Control Release(IF:5.69), Clin Cancer Res ( IF:6.25 ), J Med Chem ( IF : 4.9 ), J Pharm Exp Therapy( IF:4.3), Inter J Cancer (IF:4.7), Proteomics (IF:4.6), J Mater Chem (IF:4.33), J Chromatogr A (IF:3.75) , Cell Physiol Biochem(IF:3.52), J Mass Spectrom (IF:3.06 ) 等杂志,申请专利 19 项,授权 1 项, 承担 国家自然科学基金 课题 3 项,863重点项目1项 , 十五重大专项“天然活性产物分离分析关键技术” 1 项,省级重点项目3项,2006 年入选 “ 新世纪优秀人才支持计划 ”。

【任职】

肿瘤生物研究室副主任, 中国医药生物技术协会,纳米生物专业委员会理事;四川大学学报医学版编委

【研究方向

  天然药物活性成分的大规模分离纯化及结构修饰 •  新型缓释药物载体材料的研究   •  液相色谱与质谱技术在药物代谢及药物动力学中的研究    .  天然及小分子药物设计与开发。

【代表性论著】

•  Liu X-Y, Yang J-L, Chen L-J* , Wei Y-Q*. A review of current applications of mass spectrometry for neuroproteomics in epilepsy: many technologies one goal. Mass Spec Rev. 2010 , 29:197-246. ( IF=11.507 )

•  Luo Y-F, Zheng H, Chen L-J* , Li R , He C-M , Yang S-Y , Ye X, Chen Z-Z , Li Z-C , Gao Y , Han J , He G , Yang L , Wei Y-Q. Discovery of (Z)-5-(4-Methoxybenzylidene) thiazolidine -2, 4-dione , a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-induced Acute Liver Injury of BALB/c Mice. J Med Chem. 2010, 53(1) , 273?C281. (IF=4.898)

•  Hu J, Ye H-Y, Fu A-F, Chen X, Wang Y-S, Chen X-C, Ye X, Xiao W-J, Duan X-M, Wei Y-Q , Chen L-J*. . Deguelin-an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in lung tumor model. Inter J Cancer. 2010,126(5),1282-1292 . ( IF=4.734 )

•  Wang X-H, Zhou J-C, Wang Y-S, Zhu Z-Y, Lu Y, Wei Y-Q, Chen L-J*. A phase I clinical and pharmacokinetic study of paclitaxel liposome infused in non-small-cell lung cancer patients with malignant pleural effusions. Eur J Cancer. 2010,46(2),449-455 . ( IF=4.475 )

•  Liang S-F, Fu A-F, Zhang Q, Tang M-H, Zhou J, Wei Y-Q, Chen L-J*. Honokiol inhibits HepG2 migration via downregulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis. Proteomics. 2010, 10(3) , 349-368 ( IF=4.586 )

•  Peng X-D, Wu X-H, Chen L-J *, Wang Z-L, Hu X-H, Song L-F, He C-M, Luo Y-F, Chen Z-Z, Jin K. Lin H-G, Li X-L, Wang Y-S, Wei Y-Q. Inhibition of Phosphoinositide 3-Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice. J Pharmacol Exp Ther. 2010,332 (1), 46-56. ( IF=4.309 )

•  Ye H-Y , Zhong S-J , Li Y-F , Tang M-H , Peng A-H , Hu J , Shi J , He S-C , Wu W-S , Chen L-J *. Enrichment and isolation of barbigerone from Millettia pachycarpa Benth. using highspeed counter-current chromatography and preparative HPLC. J Sep Sci , 2010,33, 1?C8. (IF=2.746)

•  Chen X, Wang X-H , Wang Y-S, Yang L * , Hu J, Xiao W-J, Fu A-F, Cai L-L, Li X, Ye X , Liu Y-L, Wu W-S, Shao X-M, Mao Y-Q, Wei Y-Q, Chen L-J * . Improved Tumor-Targeting Drug Delivery and Therapeutic Efficacy by Cationic Liposome Modified with Truncated bFGF Peptide. J Control Release, 2010, 145,17 ?C 25 (IF=5.69)

•  Wang W-H, Fu A-F, Lan J-B, Gao Y, You J S *, Chen L-J*. Rational Design of Fluorescent Bioimaging Probes by Controlling Aggregation Behavior of Squaraines: A Special Effect of Ionic Liquid Pendants. CHEM-EUR J , 2010 , 16 , 5129 ?C 5137 (IF=5.454)

•  Xiao W-J, Chen L-J* , Chen X, Yang L, Mao Y-Q, Zhao X, Wei Y-Q . . Co-delivery of Doxorubicin and plasmid by a novel FGFR-mediated cationic liposome. Int J Pharm , 2010, 393, 119?C126 . (IF=3.061 )

•  Zhong Z-H , Wei X , Qi B-W , Xiao W-J, Fu A-F, Chen X, Hu J, Cai L-L, Yang L, Mao Y-Q, Wei Y-Q, Chen L-J * . A Fusion vaccine containing Liposomal bFGF and monophosphoryl lipid A, protect mice against tumor pulmonary metastasis. Int J Pharm , 2010. doi:10.1016/j.ijpharm.2010.07.053   ( IF=3.061 )

•  Qi B-W , Zhao Y-L , Wei X , Xiao W-J , Zheng H , Chen Z-Z, Duan X-M, Lu Y , Zhao X, Wei Y-Q, Chen L-J *. A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and cytokines in pulmonary fibrosis. Eur J Pharmacol , 2010, 10;642(1-3):134-9 . . ( IF=2.787 )

•  Shi J, Xu G-B, Chen L-J* , Peng A-H, Peng M, Luo Y-F, Ye H-Y, Zhong S-J, He S-C, Li S-C. Preparative purification of honokiol derivatives by high-speed counter-current chromatography. J Chromatogr A , 2010, 1217,3461?C3465 ( IF=3.756 )

•  W ang X-H, Zheng H, Zhu Z-Y, Wei Y-Q, Ch en L-J *. Clinical pharmacokinetics of paclitaxel liposome with a new route of administration in human based on the analysis with ultra performance liquid chromatography. J Pharm Sci-US , 2010. DOI: 10.1002/jps.22169 (I F=2.996)

•  L uo H-D, Peng M, Ye H-Y, Chen L-J * , Peng A-H, Tang M-H, Zhang F, Shi J. Linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-speed counter-current chromatography. J Chromatogr B , 2010, . 878, 1929?C1933 ( IF=2.5 )

•  Peng A-H, Ye H-Y, Shi J, HeS-C , Zhong S-J , Chen L-J*. Parameters optimization in intermittent counter-current extraction (ICcE) and comparison of throughput between ICcE and common HSCCC. J Chromatogr A,2010, 1217, 5935?C5939 ( IF=3.756 )

•  Wei X , Han J , Chen ZZ , Qi BW , Wang GC , Ma YH , Zheng H , Luo YF , Wei YQ , Chen LJ . A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun. 2010, 25;397(2):311-7.

•  Weida Wang, Afu Fu, Jingsong You, Ge Gao, Jingbo Lan, * , Lijuan Chen, * Squaraine-based colorimetric and fluorescent sensors for Cu2 t -specific detection and fluorescence imaging in living cells. Tetrahedron, 2010, 66, 3695?C3701.

•  Yinghua Ma, Xianhuo Wang, Xin wei, Liang Ma, Hao Zheng, Baowen Qi, Wei zhu, Youfu Luo, Lijuan Chen* , Yuquan Wei. (Z)-5-(4-methoxybenzylidene) thiazolidine-2, 4-dione ameliorates the adjuvant-induced arthritis via inhibiting the migration of macrophage and down-regulating the cytokine mRNA expression. International Immunopharmacology. 2010,In press.

•  Xianhuo Wang, Linyu Deng, Xia Ye , Minghai Tang , Xiang Chen, Lulu Cai, Xia Zhao, Yuquan Wei , Lijuan Chen* . Truncated BFGF-Mediated Cationic Liposomal Paclitaxel for Tumor-Targeted Drug Delivery: Improved Pharmacokinetics and Biodistribution in Tumor-Bearing Mice. J Pharm Sci-US , 2010,In press.

•  Wen J , Fu A-F , Chen L-J * , Xie X-J , Yang G-L, Chen X-C , Wang Y-S , Li J, Chen P, Tang M-H, Shao X-M , Lu Y, Zhao X , Wei Y-Q. Liposomal Honokiol Inhibits VEGF-D-induced L ymphangiogenesis and Metastasis in Xenograft Tumor Model. Inter J Cancer, 2009, 124 (11): 2709-2718. ( IF=4.734 ,)

•  Li Z-G, Zhao Y-L, Wu X-H, Ye H-Y, Peng A-H, Cao Z-X, Mao Y-Q, Zheng Y-Z, Jiang P-D, Zhao X, Chen L-J*, Wei Y-Q *. Barbigerone, a Natural Isoflavone, Induces Apoptosis in Murine Lung-Cancer Cells via the Mitochondrial Apoptotic Pathway. Cell Physiol Biochem. 2009,2495-104. ( IF=3.246 )

•  Ye H-Y, Ignatova S, Peng A-H, Chen L-J * , Sutherland I. Optimising resolution for a preparative separation of Chinese herbal medicine using a surrogate model sample system. J Chromatogr A . 2009, 1216 (26), 5101-5105. ( IF=3.756 )

•  Zhou J, Liang S-F , Fang L, Chen L-J* , Tang M-H, Xu Y-H, Fu A-F, Yang J-L, Wei Y-Q. Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. Omics. 2009, 13 (2), 93-103. ( IF=3.167 ,他引 1 次)

•  Luo Y-F, Xu Y-B, Chen L-J *, Hu J, Peng C, Xie D-C, Shi J-Y, Huang W-C, Xu G-B, Peng M, Han J, Li R, Yang S-Y, Wei Y-Q. Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol. Bioorg Med Chem Lett. 2009, 19 (16), 4702-4705. ( IF=2.531 )

•  Wang Z-L, Wu X-H, Song L-F, Wang Y-S, Hu X-H, Luo Y-F, Chen Z-Z, Jin K, Peng X-D, He C-M, Chen L-J * , Wei Y-Q *. Phosphoinositide 3-kinase c inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem Bioph Res Co . 2009,4 , 569-574. ( IF=2.648 )

•  Peng X-D , Dai L-L , Huang C-Q , He C-M , Yang B , Chen L-J * . R elationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem Bioph Res Co . 2009, 9;388(1):31-4. ( IF=2.648 )

•  Ye X, Tang M-H, Chen L-J *, Peng A-H, Ma L, Ye H-Y. Rapid separation and identification of major constituents in Pseudolarix kaempferi by ultraperformance liquid chromatography coupled with electrospray and quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Sp . 2009,23(24) : 3954-3962. ( IF=2.772 )

•  Peng X-D, Dai L-L, Huang C-Q, He C-M, Chen L-J *. Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroentero , 2009, 15 (37), 4720-4725. ( IF=2.081 )

•  Peng A-H, Ye H-Y, Li X, Chen L-J*. Preparative separation of capsaicin and dihydrocapsaicin from Capsicum frutescens by high-speed counter-current chromatography. J Sep Sci . 2009, 32 (17), 2967-2973. ( IF=2.746 )

•  Zhang Y-Y, Chen X, Lan J-B, You J-S*, Chen L-J*. Synthesis and Biological Applications of Imidazolium-Based Polymerized Ionic Liquid as a Gene Delivery Vector. Chem Biol Drug Des. 2009 ,74 (3), 282-288. ( IF=2.375 )

•  Hou W- L , Li Y-F, Zhang Q, Wei X, Peng A-H, Chen L- J * , Wei Y-Q . Triterpene Acids Isolated from Lagerstroemia speciosa Leaves as α-Glucosidase Inhibitors . Phytother Res . 2009, 23 (5), 614-618. ( IF=1.772 )

•  Peng X-D, Huang C-Q, Chen L-J* . Cognitive Behavioural Therapy and Reminiscence Techniques for the Treatment of Depression in the Elderly: a systematic review. J Inter Med Res. 20 09, 37 (4), 975-982 . ( IF=0.821 )

•  Liu X-Y, Yang J-L , Chen L-J* , Zhang Y, Yang M-L, Wu Y-Y, Li F-Q, Tang M-H, Liang S-F, Wei Y-Q. Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy. Proteomics . 2008,8,582-603. ( IF=4.586 )

•  Luo Y-F, Xu Y-B, Chen L-J* , Luo, H-D, Peng, C, Fu J, Chen H-J, Peng A-H, Ye H-Y, Xie D-C, Fu A-F, Shi J-Y, Yang S-Y, Wei Y-Q. Preparative purification of anti-tumor derivatives of honokiol by high-speed counter-current chromatography. J Chromatogr A. 2008,1178 :160?C165. ( IF=3.756 )

•  Ye H-Y, Ignatova S, Luo H-D, Li Y-F , Peng A-H, Chen L-J* , Ian Sutherland*. Preparative separation of a erpenoid and alkaloids from Tripterygium wilfordii Hook. f using high performance counter-current chromatography: comparison of various elution and operating strategies , J Chromatogr A . 2008,1213: 145?C153. ( IF=3.756 )

•  Ye H-Y, Chen L-J* , Li Y-F , Peng A-H, Fu A-F, Song H, Tang M-H, Luo H-D, Luo Y-F, Xu Y-B, Shi J-Y, Wei Y-Q. Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography. J Chromatogr A . 2008,1178: 101?C107. ( IF=3.756 )

•  Wang G-T, Li L-L, Lan J-B, Chen L-J* , You J-S*. Biomimetic Crystallization of Calcium Carbon ate Spherules Controlled by Hyperbranched Polyglycerols. J Mater Chem. 2008, 18, 2789?C2797 ( IF=4.646 )

•  Peng A-H, Li R, Hu J, Chen L-J*, ,Zhao X ? , Luo H-D, Ye H-Y, Yuan Y, Wei Y Q . Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Tripterygium wilfordii and scale-up J Chromatogr A . 2008, 1200: 129-135. ( IF=3.756 )

•  Li R, Chen W, Shi J-Y, Chen L-J* , Chen Y-C, Ding L-S, Wei Y-Q. Discovery and synthesis of a new bis(thiourea)-Pd pincer guided by ESI-MS/MS. J Mass Spectrom. 2008, 43: 542-546. ( IF=2.94 )

•  Yuan Y, Wang B-Q, Chen L-J* , Luo H-D, Fisher D, Sutherland I A. How to realize the linear scale-up process for the rapid purification using high-capacity high-speed counter-current chromatography. J Chromatogr A . 2008, 1194: 192-198 ( IF=3.756 )

•  Li R, Peng A-H, He C-M, Wang X-H, Shi J-Y, Chen L-J* , Wei Y-Q . Analysis of triptophenolide and its related compounds from Tripterygium wilfordii Hook.f by electrospray ionization tandem mass spectrometry. Int J Mass Spectrom. 2008, 278:38-49. ( IF=2.445 )

•  Hou W- L, Yang G- L, Chen L- J*, Zhong Z- H, Jiang Q- Q, Zhou H, Hu J, Chen X, Wang X-H., Yuan-Y, Tang M-H, Wen J, Wei Y-Q. Synergistic Antitumor Effects of Liposomal Honokiol Combined with Adriamycin in Breast Cancer models. Phytother Res . 2008,22: 1125-1132 . ( IF=1.772 )

•  Zhang F, Tang M-H, Chen L-J*, Li R, Wang X-H , Duan J-G, Zhao X, Wei Y-Q . Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography?Ctandem mass spectrometry and pharmacokinetics evaluation of “SHEN-FU” injectable powder. J Chromatogr B. 2008,873 , 173?C179 ( IF=2. 5 )

•  Jiang Q-Q, Fan L-Y, Yang G-L , Guo W-H, Liu L, Hou W-L, Nie X-H, Chen L- J* , Wei Y-Q* . Improved Therapeutic Effectiveness by Combining Liposomal Honokiol with Cisplatin in Lung Cancer Model. BMC Cancer. 2008, 16(8):242. ( IF=3.087 )

•  Hu J, Chen L- J*, Liu L, Chen X, Chen P, Yang G-L , Hou W-L , Tang M-H, Zhang F, Wang X-H, Zhao X, Wei Y-Q . Honokiol, A Potent A nti-angiogenesis agent, in Combination with Radiotherapy Produces Synergistic Antitumor Efficacy. Exp Mol Med. 2 008, 31;40(6):617-28. ( IF=2.376 )

•  Yuan Y, Hou W-L, Tang M-H, Wang X-H, Luo H-D, Chen L-J*, Guan H, Sutherland I-A. Separation of Flavonoids from the Leaves of Oroxylum indicum by HSCCC. Chromatographia . 2008, 68, 885?C892. ( IF=1.312 )

•  Wang X-H, Chen X, Chen L-J* , Wang B-Q, Peng C, He C-M, Tang M-H, Zhang F, Hu J, Li R, Zhao X, Wei Y-Q. Optimizing high-performance liquid   chromatography method for quantification of glucosamine using   6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivatization in rat plasma. Biomed Chromatogr. 2008, 22 : 1265?C1271. ( IF=1.592 )

•  Chen L-J * , Zhang Q, Yang G-L, Fan L-Y, Tang J, Ian G, Ignatova S, Fisher Dk and Ian A Sutherland. Rapid Purification and Scale-up of Honokioland Magnolol Using High Performance Countercurrent Chromatography. J. Chromatogr A, 1142: 115?C122, 2007 ( IF=3.756 )

•  Chen L-J , Zhao X* , Fang L-Y , Games D-E. Quantitative determination of isoflavones and their metabolites in human urine using combined liquid chromatography-mass spectrometry. J Chromatogr A. 2007, 1154: 103-110. ( IF=3.756 )

•  Yuan Z, Zhao X-Y, Yan F, Zhao J, Liu H-Y, Xiong S-Q, Li J, Wei Y- Q, Chen L-J* . beta-synucleln protein from Xenopus laevis: Overexpression in Escherichia coli of the GST-Tagged protein and production of polyclonal antibodies. Biochemistry. 2007, 72(11),1270-1278. ( IF=1.8 )

•  Zhang Q, Chen L-J* , Ye H-Y, Gao L, Hou W-H, Tang M-H, Yang G-L, Zhong Z-H, Yuan Y, Peng A-H. Isolation and purification of ginkgo flavonol glycosides from Ginkgo biloba leaves by high-speed counter-current chromatography. J Sep Sci. 2007, 30 ( 13 ): 2153-2159 . ( IF=2.746 )

•  Chen L-J , Sutherland I-A*. How to achieve rapid separations in counter-current chromatography . J Chromatogr A. 2006,1114:29-33 . ( IF=3.756 )

•  Chen L-J* , Song H, Lan X-Q, Games D-E, Sutherland I.-A. Comparison of high speed countercurrent chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum, J Chromatogr A. 2005,1063, 241-245. ( IF=3.756 )

•  Chen L-J* , Zhao X, Plummer S, Tang J, Games D-E. Quantitative determination and structural characterization of isoflavones in nutrition supplements by liquid chromatography-mass spectrometry. J Chromatogr A. 2005, 1082, 60-70. ( IF=3.756 )

•  Chen L-J* , Song H, Du Q-Z, Li J, Y. Ito. Analysis of flavonoids in the Extracts from the Seeds of Oroxylum Indicum Indicum Using High Speed Countercurrent Chromatography/Mass Spectrometry. J Liq Chromatogr Rel Technol. 2005, 28 1549-1553. (IF=1.026)

•  Chen L-J* , Song H, D.E. Games, I.A. Sutherland. HSCCC-MS Study of Flavonoids in the Extracts from the Seeds of Oroxylum indicum J. Liq Chromatogr Rel Technol - 28 ( 12-13) 2005,1993 - 2003 (IF: 0.85)

•  Chen L-J* , Games, D.E. and Jones, J. (2003) Isolation and identification of four flavonoid constituents from the seeds of Oroxylum indicum by high-speed countercurrent chromatography, J. Chromatogr A , 988, 95-105. ( IF:3.641 )

•  Chen L-J* , D.E. Games, J Jones and Huw Kidwell, Separation and Identification of flavonoids in an Extract from the Seeds of Oroxylum indicum by CCC. J. Liq Chromatogr Rel Technol . Vol 26 9&10, (2003) 1615-1628 (IF: 0.85)

 

【联系方式】

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手机: 13982090476 or 18980601790
 

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