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  郭刚
简介
   郭刚,男,博士,副研究员,博士生导师。全国生化检测标准化技术委员会委员,成都市科青联理事。2005年获四川大学材料学专业博士学位,2005.7-2007.11在四川大学师从王玉忠院士从事可降解高分子材料的博士后研究工作。2007 12 月起分别任生物治疗国家重点实验室副研究员、博士生导师。目前主要从事新型医用高分子材料/纳米生物技术领域的研究工作,在新型可降解高分子药物载体的制备与改性方面已积累了较多研究基础,尤其是在智能高分子药物载体制备以及纳米药物载体等方面有较好的前期积累。作为课题负责人和主研分别承担了国家科技重大专项、“863”计划、国家自然科学基金、中国博士后科学基金以及多项横向科研课题等项目的研究工作。目前已在国际杂志Biomaterials, Nanoscale, ACS Nano, Scientific Reports, Int J Nanomed等国际学术期刊发表论文70 余篇,其中SCI 收录60余篇;申请国家发明专利23项,其中11 项已授权,多项研究技术已在企业转化实施;担任Biomaterials Open Library编委,为Biomaterials, Nanoscale, J Biomed Nanotechnol等国际杂志特邀审稿人。获省级科技奖励两项以及成都市科技进步二等奖一项,获四川大学优秀青年骨干教师奖等荣誉。
 
研究方向
1、新型生物降解高分子材料的设计、合成与应用;
2、组织工程及再生医学材料;
3、靶向纳米药物递送系统的设计与制备。
 
招生专业
          1、药剂学。 2、纳米材料与纳米技术。3、化学生物学。
欢迎化学、材料、高分子、医学、化工以及药学专业的学生报考硕士和博士生,乐意接受推免生。同时欢迎相关专业背景的优秀本科生提前进入研究室开展科研早期训练。
 
【发表的部分论文】
1.Lan Mei, Yuelong Wang, Aiping Tong, Gang Guo*. Facile electrospinning of an efficient drug delivery. Expert Opin Drug Deliv. 2016, 25: 1-13.
2.Rangrang Fan, Xiaoling Li, Jiaojiao Deng, Xiang Gao, Liangxue Zhou*, Yu Zheng, Aiping Tong, Xiaoning Zhang, Chao You & Gang Guo*. Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity. Scientific Reports. 6:28373  DOI: 10.1038/srep28373.
3.Xiang Gao, ShiMin Wang, BiLan Wang, SenYi Deng, XiaoXiao Liu, XiaoNing Zhang, LinLi Luo, RangRang Fan, MingLi Xiang*, Chao You, YuQuan Wei, ZhiYong Qian, Gang Guo*. Improving the anti-ovarian cancer activity of docetaxel with biodegradable self-assembly micelles through various evaluations. Biomaterials. 2015, 53: 646-658.
4.Gang Guo, ShaoZhi Fu,LiangXue Zhou, Hang Liang, Min Fan, ZhiYong Qian*, YuQuan Wei.Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale. 2011, 3 (9), 3825–3832.
5.Rangrang Fan, Aiping Tong,  Xiaoling Li, Xiang Gao, Lan Mei, Liangxue Zhou*, Xiaoning Zhang, Chao You,Gang Guo*. Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer. Int J Nanomedicine. 2015, 10: 7291–7305
6.YueLong Wang, JiaoJiao Deng, RangRang Fan, AiPing Tong*, XiaoNing Zhang, LiangXue Zhou, Yu Zheng, JianGuo Xu and Gang Guo*. Novel nanoscale topography on poly(propylene carbonate)/poly(ε-caprolactone) electrospun nanofibers modifies osteogenic capacity of ADCs. RSC Adv. 2015, 5: 82834-82844.
7.Xiaoling Li, Rangrang Fan, Aiping Tong*, Meijia Yang, Jiaojiao Deng, Liangxue Zhou, Xiaoning Zhang, Gang Guo*. In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing. Int J Pharm. 2015, 495(1): 560-571.
8.JiaoJiao Deng, YueLong Wang, LiangXue Zhou*, MaLing Gou, Na Luo, HaiFeng Chen, AiPing Tong, Chao You, Gang Guo*. Fabrication and in vivo chondrification of Poly(propylene carbonate)/l-lactide-grafted tetracalcium phosphate electrospun scaffold for cartilage tissue engineering. RSC Adv. 2015, 5: 42943–42954.
9.Xiaoling Li, Rangrang Fan, Yuelong Wang, Min Wu, Aiping Tong*, Juan Shi, Mingli Xiang, Liangxue Zhou and Gang Guo*. In situ gel-forming dual drug delivery system for synergistic combination therapy of colorectal peritoneal carcinomatosis. RSC Adv. 2015, 5: 101494-101506.
10. YueLong Wang,Gang Guo*, HaiFeng Chen,Xiang Gao, RangRang Fan,DongMei Zhang,LiangXue Zhou*. Preparation and characterization of polylactide/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) hybrid fibers for potential application in bone tissue engineering. Int J Nanomedicine. 2014, 9: 1-13.
11. RangRang Fan, YueLong Wang, Bo Han, YouFu Luo*, LiangXue Zhou, XiRui Peng, Min Wu, Yu Zheng, Gang Guo*. Docetaxel load biodegradable porous microspheres for the treatment of colorectal peritoneal carcinomatosis. Int J Biol Macromol. 2014, 69: 100-107.
12. RangRang Fan,XiaoHui Deng,LiangXue Zhou,Xiang Gao,Min Fan,YueLong Wang,Gang Guo*. Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials. Int J Nanomedicine. 2014, 9(1): 615-626.
13. RangRang Fan,LiangXue Zhou, Wei Song, DeXia Li, DongMei Zhang, Rui Ye, Yu Zheng, Gang Guo*. Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay.Int J Biol Macromol. 2013, 59: 227–234.
14. DongMei Zhang, AiPing Tong*, LiangXue Zhou, Fang Fang, Gang Guo*. Osteogenic differentiation of human placenta-derived mesenchymal stem cells (pmscs) on electrospun nanofiber meshes. Cytotechnology. 2012, 64(6), 701-710.
15. Xiang Gao, FengJin Zheng, Gang Guo(co-first author), XiaoXiao Liu, Rangrang Fan, Zhiyong Qian,   Ning Huang*, Yuquan Wei. Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles. J Mater Chem B. 2013, 1(42): 5778-5790.
 
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