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  郑瑀

个人简历

【简历】

郑瑀,女,博士,副研究员,1982年生。2004年毕业于四川大学华西药学院药学专业学习并获学士学位,2009年毕业于四川大学药学院药剂学专业学习并获博士学位,2008年至2009年在美国俄亥俄州立大学药学院药剂专业Robert J.Lee课题组作访问学者。2012年起任生物治疗国家重点实验室副研究员。近年来主要从事小分子药物、蛋白或基因药物新型靶向载体的研制,固体制剂或半固体制剂的研制,以及其他一些传统制剂的研制。主持1项国家自然科学基金,并参与4项自然科学基金。现已以第一作者或通讯作者身份在INT J PHARM, J DRUG TARGET, DRUG DELIV, J BIOTECHNOL等学术期刊上发表论文近10篇。以上论文曾被ACS nanoBiomaterialsJ Control Release, Adv Polym Sci等著名学术期刊引用,总累计引用次数达30余次。申报中国发明专利3项。为Hum Gene Ther J Biomed Nanotechnol, J DRUG TARGET等杂志的特约审稿人。

【任职】(1)中华中医药学会会员(2American Association of Pharmaceutcal scientists(AAPS)会员

【招生专业】药剂学

【研究方向】小分子药物、蛋白或基因药物新型给药系统,新型肿瘤靶向制剂,传统新制剂的开发,新型纳米给药系统

【代表性著作】

1,Jie  Tang, Jin-Ying  Chen, Jing  Liu, Min  Luo, Ying-Jing  Wang, Xia-wei  Wei,  Xiang  Gao, Bi-lan  Wang, Yi-Bo  Liu, Tao  Yi,  Ai-Ping  Tong,  Xiang-Rong  Song, Yong-Mei  Xie, Yinglan  Zhao, Mingli  Xiang, Yuan  Huang, Yu  Zheng*, Calcium  phosphate  embedded  PLGA  nanoparticles:  A  promising  gene  delivery vector with high gene loading and transfection ef?ciency, International Journal of Pharmaceutics, 2012(431):210-221 (IF3.7)

2,Jing Liu, Jie Tang, Hai-Yu He, Lu-Lu Cai, YiMei Huang, Xiawei Wei, Min Luo, Bilan Wang, Xiang Gao, Chengli Yang, Tingting Hu, Xiangrong Song, Tao Yi, Li Yang, Yongmei Xie, Aiping Tong, Lantu Gou, Yinglan Zhao and Yu Zheng*. Preparation of the thienopyridine derivatives loaded liposomes and study on the effect of compound-lipid interaction on release behavior, Drug delivery,2012; 19(5): 247–254 (IF:1.25)

3,唐劼,刘静,胡廷婷,杨成莉,郭刚,何谷,黄园,郑瑀*,壳核型磷酸钙/pDNA 复合物-PLGA 纳米粒的制备及体外研究,药学学报Acta Pharmaceutica Sinica 2013, 48 (2): 298304

4,Yu Zheng , Xiangrong Song , Gu He , Zheng Cai , Yan Zhou , Bo Yu , Jiapeng Xu , Yuquan Wei ,Shixiang Hou, Receptor-mediated gene delivery by folate-poly(ethylene

glycol)-grafted-trimethyl chitosan in vitro, Journal of Drug Targeting, 2011; 19(8): 647–656IF:2.7

5,Yu Zheng, Xiangrong Song, Michael Darby, Yufeng Liang, Ling He, Zheng Cai, Qiuhong Chen, Yueqi Bi, Xiaojuan Yang, Jiapeng Xu, Yuanbo Li, Yiyi Sun, Shixiang Hou. Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate-receptor mediated endocytosisJournal of Biotechnology, 2010145(1):47-53(IF:2.7).

6,Yu Zheng, Bo Yu, Wanlop Weecharangsan, Longzhu PiaoMichael Darby, Rumiana Koynova, Xiaojuan Yang, Hong Li, L. James Lee, Yasuro Sugimoto Robert W.  Brueggemeier Robert J. Lee. Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7α-APTADD to breast cancer cells. International Journal of Pharmaceutics, 2010, 390(2):234-41. (IF:3.0).

7,Yu Zheng, Zheng Cai, Xiangrong Song, Qiuhong Chen, Yueqi Bi, Yuanbo Li, Shixiang Hou. Preparation and characterization of folate conjugated N-trimethyl chitosan nanoparticles as protein carrier targeting folate receptor: in vitro studies. Journal of drug targeting, 200917(4): 294-303(IF:2.7)

8,Yu Zheng, Zheng Cai, Xiangrong Song, Bo Yu, Yueqi Bi, Qiuhong Chen, Dong Zhao, Jiapeng XuShixiang Hou. Receptor mediated gene delivery by folate conjugated N-trimethyl chitosan in vitro. International Journal of Pharmaceutics, 2009382: 262-269IF: 3.0).

9郑瑀 侯世祥. 壳聚糖及衍生物作为抗肿瘤药物载体的研究进展. 中华中医药学会制剂分会第九届学术研讨会论文集,2008

10,郑瑀,侯世祥,陈彤,卢懿. 3种药物传递体的制备及其包封率、体外释放的比较研究. 中国中药杂志, 2006,31(9),728-731(MEDLINE)

【联系方式】 

电话: 15828519279

Email: zhengyu_iris@163.com               

QQ373620497

【地址】 

四川大学华西校区 药化路 生物治疗国家重点实验室 纳米生物技术与药物传递系统实验室

 

 

生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041