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  黄灿华
黄灿华:四川大学生物治疗国家重点实验室,教授,博士生导师。
  
 
【简历】
      2000年在中国科学院获博士学位,随后在新加坡国立大学生物系从事博士后研究。2003 年8月被新加坡国立大学肿瘤研究所聘为Research Scientist。2005年9月回国任四川大学生物治疗国家重点实验室教授。国家杰出青年科学基金获得者(2012);国家重大科学研究计划(973计划) “病毒诱导肿瘤发生的氧化还原蛋白质组研究”项目首席科学家(2013-2017);教育部长江学者特聘教授(2014-)。
  回国以来以通讯作者在Mol Cell Proteomics (5篇)、Gastroenterology、Cancer Res (3篇,包括2013封面论文)、Nat Microbiol、 Autophagy (5篇)、Cell Death Differ、PLoS Pathog、J Cell Sci、J Infect Dis、Carcinogenesis 等学术刊物上发表SCI论文60余篇,其中30余篇论文影响因子大于5.0,被引用1400余次。受邀请在 Mass Spectrom Rev、Med Res Rev、Expert Rev Proteomics  等国际学术刊物上发表多篇关于系统生物学前沿综述。中国生物化学与分子生物学会蛋白质组学专业委员会委员;中国生物化学与分子生物学会代谢专业委员会委员;中国药理学会精准分析药理学专业委员会常务委员;中国转化医学联盟第一届理事会常务理事;中国抗癌协会肿瘤标志专业委员会第六届委员会常务委员;中国抗癌协会肿瘤转移专业委员会第四届委员会委员。国际学术刊物  Proteomics、Signal Transduction and Targeted Therapy 等编委委员。
 
【研究方向】
   (1) 氧化还原信号调控与肿瘤发生;
   (2) 病毒诱发癌变的分子机理;
   (3) 系统生物学筛选药物靶标。
【联系方式】
    邮箱:hcanhua@hotmail.com (常用); hcanhua@scu.edu.cn
    电话:+86-13258370346
    实验室主页:www.hcanhua.icoc.cc
 
【代表性论著】( * 为通讯作者 )
1.       Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C*. Ivermectin Induces PAK1-mediated Cytostatic Autophagy in Breast Cancer. Autophagy. 2016;12(12)2498-2499 (IF=11.753)
2.       Dou Q, Chen H, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y and Huang C*. Ivermectin induces cytostatic autophagy by blocking PAK1/Akt axis in breast cancer. Cancer Res. 2016; 76(15):4457-69. (IF=9.329)
3.       Xie N, Yuan K, Zhou L, Wang K, Chen H, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H*, Yang J* and Huang C*. PRKAA1/AMPK restricts HBV replication through promotion of autophagic degradation. Autophagy. 2016; 12(9):1507-20. (IF=11.753)
4.        Liu Y, Li Q, Zhou L, Xie N, Nice EC, Zhang H*, Huang C* and Lei Y*. Cancer drug resistance: redox resetting renders a way. Oncotarget. 2016. doi: 10.18632/oncotarget.8600. (IF=6.627)
5.       Huang Z, Zhou L, Chen Z, Nice EC, Huang C*. Stress Management by Autophagy: Implications for Chemoresistance. Int J Cancer. 2016; 139(1):23-32. (IF=5.085)
6.        Chen HN, Yuan K, Xie N, Wang K, Huang Z, Chen Y, Dou Q, Wu M, Nice EC, Zhou ZG*, Huang C*. PDLIM1 stabilizes the E-cadherin/Beta-catenin complex to prevent epithelial-mesenchymal transition and metastatic potential of colorectal cancer cells. Cancer Res. 2016; 76(5):1122-34. (IF=9.329)
7.        Yuan K, Lei Y, Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu Min, Xiang R, Feitelson MA, Nice EC, Wei Y, Huang C*. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. Cell Death Differ. 2016; 616–627 (IF=8.184)
8.        Li X, He S, Zhou X, Ye Y, Tan S, Zhang S, Li R, Yu M, Jundt MC, Hidebrand A, Wang Y, Li G*, Huang C*, Wu M*. Lyn delivers bacteria to lysosomes for eradication through TLR2-initiated autophagy related phagocytosis. PLoS Pathog. 2016; 12(1):e1005363. (IF= 7.562)
9.        Zhang L, Wang K, Lei Y, Li Q, Nice EC, Huang C*. Redox Signaling: Potential Arbitrator of Autophagy and Apoptosis in Therapeutic Response. Free Radical Bio Med. 2015; 89:452-465. (IF= 5.736)
10.     Li X, Ye Y, Zhou X, Huang C*, Wu M*. Atg7 Enhances Host Defense against Infection via Downregulation of Superoxide but Upregulation of Nitric Oxide. J Immunol. 2015; 194(3):1112-21. (IF=5.362)
11.     Liu R, Huang S, Lei Y, Zhang T, Wang K, Liu B, Nice EC, Xiang R, Xie K, Li J*, Huang C*. FGF8 promotes colorectal cancer growth and metastasis by activating YAP1. Oncotarget. 2015; 6(2):935-52. (IF=6.627)
12.     Lei Y, Wang K, Deng L, Chen Y, Nice EC, Huang C*. Redox Regulation of Inflammation: Old Elements, a New Story. Med Res Rev. 2015; 35(2):306-40. (IF=8.13)
13.     Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C*, Wei Y. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking. Autophagy. 2014; 10(7):1241-55. (IF=11.753)
14.     Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C*, Wei Y. FGFR4 promotes stroma-induced epithelial to mesenchymal transition in colorectal cancer. Cancer Res. 2013; 73(19):5926-35. (2013, Oct 1st, 封面论文;Highlighted as breaking advance in Cancer Res, 2013, Oct 15th ) (IF=9.3)
15.     Wen X, Wu J, Wang F, Liu B*, Huang C*, Wei Y. Deconvoluting the role of reactive oxygen species and autophagy in human diseases. Free Radic Biol Med. 2013; 65:402-10. (IF=5.27)
16.     Liu R, Huang L, Li J, Zhou X, Zhang H, Zhang T, Lei Y, Wang K, Xie N, Zheng Y, Wang F, Nice EC, Rong L, Huang C*, Wei Y. HIV Infection in Gastric Epithelial Cells. J Infect Dis. 2013; 208(8):1221-30. (IF=5.85).
17.     Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C*, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer. Carcinogenesis. 2013; 34(12):2861-9. (IF=5.64)
18.     Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C*, Wu M*. Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Tumor Growth and Metastasis in Mice. Gastroenterology. 2013; 145(4):853-64.e9. (IF= 18.187)
19.     Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK 3rd, Huang C*, Wei Y. Pyrvinium targets autophagy addiction to promote cancer cell death. Cell Death Dis. 2013; 4:e614. (IF=6.04)
20.     Wang K, Zhang T, Dong Q, Nice EC, Huang C*, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis. 2013; 4:e537. (IF=6.04)
21.     Zhou S, Liu R, Yuan K, Yi T, Zhao X, Huang C*, Wei Y. Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis. Mass Spectrom Rev. 2013; 32(4):267-311. (IF=7.74)
22.     Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X*, Huang C*, Wei Y. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics. 2012; 11(7):M112.017988. (IF=9.43)
23.     Yuan K, Huang C*, Fox J, Weaver A, Li GP, Singh BB, Gao H, Wu M*. Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci. 2012; 125:507-515. (IF = 6.11)
24.     Lei Y, Huang K, Gao C, Lau QC, Pan H, Xie K, Li J, Liu R, Zhang T, Xie N, Shan Nai H, Wu H, Zhao X, Dong Q, Nice E, Huang C*, Wei Y. Proteomics identification of ITGB3 as a key regulator in ROS-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics. 2011; 10(10):M110.005397. (IF=9.43)
25.     Yuan K, Huang C*, Fox J, Gaid M, Weaver A, Li GP, Singh BB, Gao H, Wu M*. Elevated inflammatory response in Caveolin-1 deficient mice with P. aeruginosa infection is mediated by STAT3 and NF-{kappa}B. J Biol Chem. 2011; 286(24):21814-25. (IF=5.33)
26.     Zhou S, Li Y, Huang F, Zhang B, Yi T, Li Z, Luo H, He X, Zhong Q, Bian C, Lin X, Qi X, Liu P, Huang C, Zhao X*, Wei Y. Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation. Cancer Lett. 2012 May 1;318(1):14-25.(IF=5.992
27.     Wang K, Liu R, Li J, Mao J, Xie N, Wu J, Lei Y, Zhang T, Zeng J, Wu H, Chen L, Huang C.* Wei Y.  Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011; 7(9):966-78. (IF=11.753)
28.     Li J, Liu R, Lei Y, Wang K, Lau Q.C, Xie N, Zhou S, Nie C, Chen L, Wei Y, and Huang C*. Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010; 6(6) :711-24 (IF=11.753)
29.     Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Zeng D, Tong A, Chen L, Wei Y, Huang C*.  Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 2010; 9:81. (IF=5.36)
30.     Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, Chen L, Liang S, Zhao Y, Wei Y, Huang C*. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone mediated gastric carcinogenic signaling pathway. Mol Cell Proteomics. 2009; 8(1):70-85. (IF=9.43)
31.     Li Z, Zhao X*, Bai S, Wang Z, Chen L, Wei Y, Huang C*. Proteomic identification of cyclophilin A as a potential prognostic factor and therapeutic target in endometrial carcinoma. Mol Cell Proteomics. 2008; 7(10):1810-1823. (IF=9.43)
32.     Wang Z, Jiang L, Huang C*, Li Z, Tong A, Chen L, Shen J, Gao F, Chen Q*. Comparative proteomic approach to screening of potential diagnostic and therapeutic targets for Oral Squamous Cell Carcinoma. Mol Cell Proteomics. 2008; 7:1639–1650. (IF=9.43)
33.     Tong A, Gou L, Lau Q, Li J, Zhao X, Chen L, Tang H, Huang C*, and Wei Y*. Proteomic Profiling Identifies Aberrant Epigenetic Modifications Induced by Hepatitis B Virus X Protein. J Proteome Res. 2009; 8(2):1037-46. (IF=5.67)
34.     Tong A, Wu L, Lin Q, Lau Q, Li J, Chen L, Tang H, Huang C, and Wei Y*. Proteomic analysis of cellular protein alterations using a HBV-producing cellular model. Proteomics. 2008; 8:2012-2023. (IF=5.57)
35.     Li Z, Huang C*, Bai S, Pan X, Zhou R, Wei Y, and Zhao X*. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. Int J Cancer. 2008; 123:2377-2383. (IF=5.35)
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041