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  李炯

【简历】

李炯,女,1975年生,博士,副研究员,博士研究生导师,国家自然科学基金同行评议专家,Immunotherapy Molecular PharmaceuticsHuman Gene TherapyActa Biochimica et Biophysica Sinica、中国细胞生物学等杂志特邀审稿人,四川省免疫学会肿瘤免疫专业委员会委员。从2001年起至今在四川大学生物治疗国家重点实验室从事科研与研究生教学工作,致力于肿瘤、自身免疫性疾病机制研究及重组蛋白治疗药物研发工作。作为课题负责人及主研先后承担和参与了国家科技重大专项、国家自然科学基金、国家“973”、国家“863”、国家自然基金创新群体基金、四川省科技应用基础研究计划等多项课题研究工作。近几年来以通讯作者和第一作者在J Immunol.Neoplasia 等杂志上发表研究论文多篇,已经申请和授权了多项相关国家发明专利。 

【研究方向】

致力于肿瘤、自身免疫性疾病的机制研究;课题组在重组蛋白药物研发具有丰富的经验,特别欢迎对生物药物研发感兴趣的同学报考。

 

【代表性论著】

1. Teng XHu ZL Wei XQWang ZGuan TLiu N , Liu X, Ye N, Deng GH , Luo C, Zhou XK, Huang NY, Sun CY, Xu MY, Deng HX, Edwards,III CK, Chen XC, Wang XX, Cui KJ, Wei YQ,LiJ.IL-37 Ameliorates the Inflammatory Process in Psoriasis by Suppressing Proinflammatory Cytokines Production. J Immunol. 2014 Feb 15;192(4):1815-23. [通讯作者]

2. Zhou X, Li J, Wang Z, Chen Z, Qiu J, Zhang Y, Wang W, Ma Y, Huang N, Cui K, Li J, Wei YQ. Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes. Neoplasia. 2013 May;15(5):544-53. [通讯作者]

3. Liu X, Wang Z, Ye N, Chen Z, Zhou X, Teng X, Huang N, Liu N, Zhang N, Guan T, Mao Y, Kan B, Wei Y, Li J. A protective role of IL-30 via STAT and ERK signaling pathways I n macrophage-mediated inflammation. Biochem Biophys Res Commun. 2013 May 31;435(2):306-12. [通讯作者]

4. Wang Z, Zhou X, Li J, Liu X, Chen Z, Shen G, Guan T, Ye N, Wei X, Huang N, Yang L, Wei Y, Li J. Suppression of hepatoma tumor growth by systemic administration of the phytotoxin gelonin driven by the survivin promoter. Neoplasma. 2013;60(5):469-79. [通讯作者]

5. X. Zhou, J. Qiu, Z. Wang, N. Huang, X. Li, Q. Li,, J. Li , In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin , J Cancer Res Clin Oncol , 2012,138(7), pp 1081-90 [通讯作者]

6. N. N. Zhang, N. Y. Huang, X. K. Zhou, X. L. Luo, C, J. Li , Protective effects of IL-4 on Bacillus Calmette-Guerin and lipopolysaccharide induced immunological liver injury in mice , Inflamm Res , 2012, 61(1), pp 17-26 [通讯作者]

7. Cui K, Chen X, Li J. Slow pathway ablation using electro-anatomical mapping in a patient with corrected transposition of the great arteries, dextrocardia, and atrioventricular nodal reentrant tachycardiaEuropace. 2013 Jan;15(1):155 [通讯作者]

8. Zhou X, Li X, Gou M, Qiu J, Li J, Yu C, Zhang Y, Zhang N, Teng X, Chen Z, Luo C, Wang Z, Liu X, Shen G, Yang L, Qian Z, Wei Y, Li J. Antitumoral efficacy by systemic delivery of heparin conjugated polyethylenimine-plasmid interleukin-15 complexes in murine models of lung metastasis , Cancer Sci , 2011, 102(7), pp 1403-9 [通讯作者]

9. Li J, Li X, Zhang Y, Zhou XK, Yang HS, Chen XC, Wang YS, Wei YQ, Chen LJ, Hu HZ, Liu CY. Gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal delivery of interleukin-4 using ultradeformable cationic liposome , JOURNAL OF GENE MEDICINE , 2010, 12(6), pp 481-490  [第一作者]

10. Zhang Y, Li J, Liu CY, Zhou XK, Qiu J, Zhang YB, Huang NY, Li Y, Chen XJ, Li XL, Wang YS, Yang HS, Chen XC, Kan B, Mao YQ, Deng HX, Yang L, Wen YJ, Zhao X, Wei YQ. , A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis , DERMATOLOGY, 2010,  221(1), pp 84-92  [通讯作者]

11. Chen X, Zhang Y, Liu C, Zhang Y, Zhou X, Zhou T, Mao Y, Kan B, Wei YQ, Li J., Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration , DRUG DELIVERY , 2010, 17(6), pp 385-390 [通讯作者]

12. Ren X, Li J, Zhou X, Luo X, Huang N, Wang Y, Chen X, Wei Y. Recombinant Murine Interleukin 4 Protein Therapy for Psoriasis in a Transgenic VEGF Mouse Model , DERMATOLOGY , 2009, 219(3), pp 232-238 [通讯作者]

13. .Cui K, Zhou X, Luo J, Feng J, Zheng M, Huang D, Jiang J, Chen X, Wei Y, Li J, Yang L. Dual gene transfer of bFGF and PDGF in a single plasmid for the treatment of myocardial infarction. Exp Ther Med. 2014 Mar;7(3):691-696. [共同通讯作者]

14. Y. Yao, J. Li, Z. Lu, A. Tong, W. Wang, X. Su, Y., Y. Wei , Proteomic analysis of the interleukin-4 (IL-4) response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.15 , Electrophoresis , 2011,32(15), pp 2004-12 [共同第一作者]

 

【联系方式】

邮箱: lijionghh@sina.com

 

 

生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041