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  何谷

 

【简   历】
 
何谷,1982年出生, 副研究员,博士生导师,2002年本科毕业于四川大学,2008年毕业于四川大学华西药学院(获药物化学专业博士学位)。作为项目负责人,在研国家自然基金面上项目1项、国家自然基金青年项目1项、教育部博士点基金1项、完成了四川大学青年科学基金项目1项;作为项目副组长,在研国家科技重大专项项目2项、国家自然基金3项及教育部博士点基金1项,完成了863项目1项、四川大学青年科学基金项目1项;还参与完成了国家自然基金面上项目1项。先后发表国内外SCI论文20余篇,申请发明专利6项。
 
【招生专业】
 
 药物化学
 
【研究方向】
 
小分子药物的设计合成、作用机制和药物靶向传递系统的研究
 
【代表性论著】
 
[1] He, Gu; Qiu, Minghua; Li, Rui; Ouyang, Liang; Wu, Fengbo; Song, Xiangrong; Cheng, Li; Xiang, Mingli; Yu, Luoting, Multicomplex-Based Pharmacophore-Guided 3D-QSAR Studies of N-Substituted 2'-(Aminoaryl)Benzothiazoles as Aurora-A Inhibitors, Chemical Biology & Drug Design, 2012, 79(6), 960-971.
[2] Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He Gu, Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan, Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives, Bioorganic & Medicinal Chemistry Letters, 2012, 22(9), 3044-3049.
[3] Cai Lulu, Qiu Neng, Li Xia , Luo Kaili, Chen Xiang, Yang Li, He Gu, Wei Yuquan, Chen Lijuan, A novel truncated basic fibroblast growth factor fragment-conjugated poly(ethylene glycol)-cholesterol amphiphilic polymeric drug delivery system fortargeting to the FGFR-overexpressing tumor cells, International Journal of Pharmaceutics2011, 4081-2),173-182.
[4] He Zhiyao, Zheng Xi, Wu Xiaohua, Song Xiangrong, He Gu, Wu Wenfang, Yu Shui, Mao Shengjun, Wei Yuquan. Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery,International Journal of Pharmaceutics2010, 3971-2),147-154.
[5] Li Junmin, He Zhiyao, Zheng Yu, Li Rtui, Yu Shui, Li Shuangzhi, Ma Qing, Yu Yiyi, He Gu, Song Xiangrong. Micelles based on methoxy poly(ethylene glycol)-cholesterol conjugate for controlled and targeted drug delivery of a poorly water soluble drug. J Biomed Nanotechnol. 2012, 8(5): 809-827.
[6]He Dongsheng, He Gu, Guo Li, Synthesis of Dendritic Tryptophan Derivatives and Investigation on Dendritic Effects of their Fluorescence and Reactivity, Letters in Organic Chemistry, 2011, 8(7), 454-460.
[7] He Gu, He Zhiyao, Zheng Xi, Li Junmin, Liu Chi, Song Xiangrong, Ouyang Liang, Wu Fengbo,Synthesis, Characterization and In Vitro Evaluation of Self-Assembled poly(ethylene glycol)-glycyrrhetinic Acid Conjugates, Letters in Organic Chemistry,2011, 9(3), 202-210.
[8] He Gu, Qiu Minghua, Li Rui, Song Xiangrong, Zheng Xi, Shi Jianyou, Xu Guobing, Han Jing, Yu Luoting, Yang Shengyong, Chen Lijuan, Wei Yuquan, Molecular docking-based 3D-QSAR studies of pyrrolo[3,4-c]pyrazole derivatives as Aurora-A inhibitors, Molecular Simulation, 2011, 37(1),31-42.
[9] He Gu, Guo Li, Cheng Lin, Zhang Yu, Jiang Bo. Convergent synthesis of second generation CCK-functional Dendrimers. Chinese Chemical Letters, 2009, 20(1), 9-12.
[10] Ouyang Liang, Huang Wencai, He Gu, Guo Li. Bone Targeting Prodrugs Based on Peptide Dendrimers, Synthesis and Hydroxyapatite Binding In Vitro. Letters in Organic Chemistry, 2009, 6(4), 272-277.
 
【联系方式】
联系电话:13551162426
 
电子邮箱:valleyhe@163.com
 
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041