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招生简章
博士生导师
硕士生导师
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研究生会
 
  巩长旸

【简历】
巩长旸,研究员,博士生导师。入选2014年“万人计划”青年拔尖人才,2013年全国百篇优秀博士学位论文提名奖,2013年四川省百篇优秀博士学位论文,四川省学术和技术带头人后备人选。1999-2003年就读于四川大学生物工程专业,获理学学士学位。2005年在四川大学生物治疗国家重点实验室攻读博士学位(硕博连读),在著名肿瘤治疗学家魏于全院士的指导下完成博士论文研究工作。2010年获四川大学细胞生物学专业博士学位,同年7月起任四川大学华西医院生物治疗国家重点实验室助理研究员、副研究员、研究员。主要研究领域为靶向药物和基因递送系统、新型免疫佐剂、纳米生物技术、医用生物材料、肿瘤治疗。主持国家自然科学基金、教育部博士点基金、四川省科技支撑计划等多项国家及省部级基金项目。参与科技部863重点项目纳米生物材料研发、科技部“重大新药创制”科技重大专项、科技部863子课题聚合物纳米载药系统的研究等多项课题的研究工作。申报中国发明专利5项。现已发表SCI学术论文90余篇论文被引用2300余次,他引2000次,h-index27其中,以通讯和第一作者Adv Mater (IF=18.96), ACS Nano (IF=13.334), Adv Funct Mater (IF=11.382), Theranostics (IF=8.854), Biomaterials (IF=8.387), Nanoscale (IF=7.76), ACS Appl Mater Inter (IF=7.145) 等国际杂志发表SCI论文60余篇(IF>10论文4篇,10>IF>5论文22篇)。J Biomed Nanotechnol, Colloid Surface B, Curr Med ChemCurr Drug Metab期刊邀请撰写特邀综述4。任BioMed Research International (原名Journal of Biomedicine and Biotechnology, SCI)International Scholarly Research NoticesAdvances in Pharmaceutics等杂志编委。为Biomaterials, Biomacromolecular, Nanoscale, Nanomed-Nanotechnol, Oncotarget, PolymChem, Nanomedicne30余种国际期刊审特邀稿人
 
研究方向与研究生招生
将新型纳米递送系统用于肿瘤治疗研究是当前生物医学领域的研究前沿和热点。本课题组围绕靶向药物和基因递送系统领域的重大需求开展应用基础研究,以新型可生物降解材料合成为基础,在生物医学工程与药剂学、纳米生物学、生物材料学、临床医学等交叉领域,开展新型靶向药物和基因递送系统、新型免疫佐剂、纳米生物技术和医用生物材料在肿瘤治疗中的应用基础研究,为肿瘤治疗研究提供了新思路,为发展新型抗肿瘤药物传递系统提供了理论依据和方法支撑。
主要研究方向:
1. 新型靶向药物和基因递送系统;
2. 新型免疫佐剂;
3. 纳米生物技术;
4. 医用生物材料。
欢迎药学、生命科学、材料学、基础及临床医学、化学等相关专业背景的同学报考硕士和博士研究生,乐意接受推免生。欢迎相关专业优秀本科生到本课题组实习。
 
【学术任职】
a) 任SCI收录学术期刊BioMed Research International(原名Journal of Biomedicine and Biotechnology, IF=2.1)编委;
b) 任学术期刊International Scholarly Research Notices编委;
c) 任学术期刊Advances in Pharmaceutics编委;
d) 多次担任Biomaterials, Biomacromolecular, Nanoscale, Nanomed-Nanotechnol, Oncotarget, PolymChem, Nanomedicne等30余种国际SCI学术期刊特邀审稿人。
 
【代表性论著】( 仅列IF>5论文,*为通讯作者,#为共同第一作者)
26. Ling Li, et al., Changyang Gong*. Multifunctional Nucleus-targeting Nanoparticles with Ultra-high Gene Transfection Efficiency for In Vivo Gene Therapy. Theranostics, 2017, 7 (6), 1633-1649. IF=8.854
25. Zichao Luo, et al., Xingyi Li*,Changyang Gong* Zhimou Yang*.A powerful CD8+ T-cell stimulating D-tetra-peptide hydrogel as a very promising vaccine adjuvant. Adv Mater, 2017, 29(5), 1601776. IF=18.96
24. Ling Li, et al., Shaohua Yao*, Changyang Gong*, Yuquan Wei*. Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice. ACS Nano, 2017, 11(1), 95-111. IF=13.334
23. Tao He, et al., Yingtai Chen*, Changyang Gong*. Improving anti-adhesion effect of thermosensitive hydrogel with sustained release of tissue-type plasminogen activator in a rat repeated-injury model. ACS Appl Mater Inter, 2016, 8(49), 33514-33520. IF=7.145
22. Ling Li, et al.Changyang Gong*. Multifunctional “core-shell” nanoparticles-based gene delivery for treatment of aggressive melanoma. Biomaterials, 2016, 111, 124-137. IF=8.387
21. Linjiang Song, et al., Li Yang*, Qinjie Wu*, Changyang Gong*. Peritoneal adhesion prevention with a biodegradable and injectable N,O-carboxymethyl chitosan-aldehyde hyaluronic acid hydrogel in a rat repeated-injury model. Sci Rep, 2016, 6, 37600. IF=5.228
20. Huaimin Wang, et al., Changyang Gong*, Xingyi Li*, Zhimou Yang*. Enzyme-Catalyzed Formation of Supramolecular Hydrogelsas Promising Vaccine Adjuvants. Adv Funct Mater, 2016, 26 (11), 1822-1829. IF=11.382
19. Ning Wang, et al., Changyang Gong*. Paclitaxel and tacrolimus co-encapsulated polymeric micelles enhance therapeutic effect of drug-resistant ovarian cancer. ACS Appl Mater Inter, 2016, 8, 4368-4377. IF=7.145
18. Qinjie Wu, et al., Changyang Gong*. Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model. Sci Rep, 2015, 5, 13533. IF=5.228
17. Xi Yang, et al., Changyang Gong*. Curcumin-encapsulated polymeric micelles suppress the development of colon cancer in vitro and in vivo. Sci Rep, 2015, 5, 10332. IF=5.228
16. Senyi Deng, et al., Changyang Gong*. Biodegradable polymeric micelle-encapsulated doxorubicin suppresses tumor metastasis by killing circulating tumor cells. Nanoscale, 2015, 7, 5270-5280. IF=7.76
15. Nannan Zhang, et al., Changyang Gong*.Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale, 2015,7(6), 2609-2624. IF=7.76
14. Yishan Chen,et al., Changyang Gong*. Polymeric micelles encapsulating fisetinimprove the therapeutic effect in colon cancer. ACS Appl Mater Inter, 2015, 7(1), 534-542. IF=7.145
13. Qinjie Wu, et al., Changyang Gong*. Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. Nanoscale, 2014, 6(20): 11940-11952. IF=7.76
12. Yuanyuan Liu, et al., Changyang Gong*, YoufuLuo*. Biodegradable nanoassemblies of piperlongumine display enhanced antiangiogenesis and antitumor activities. Nanoscale, 2014, 6, 4325-4337. IF=7.76
11. Ling Li, et al., Changyang Gong*. Biodegradable and injectable hydrogel based on chitosan and hyaluronan for prevention of postoperative adhesion. Biomaterials, 2014, 35(12), 3903-3917.IF=8.387
10. Qinjie Wu, et al., ChangYang Gong*. Biodegradable polymeric micelle-encapsulated quercetin suppresses tumor growth and metastasis in both transgenic zebrafish and mouse models. Nanoscale 2013, 5(24): 12480-12493. IF=7.76
9. ChangYang Gong, et al., Zhiyong Qian*. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 2013, 34(27): 6377-6387. IF=8.387
8. ChangYang Gong*, et al. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 2013, 34: 1413-1432. IF=8.387
7. ChangYang Gong, et al. Carrier-free nanoassemblies of a novel oxazolidinonecoumpound FYL-67 display antimicrobial activeity on methicillin-resistant Staphylococcus aureus. Nanoscale 2013, 5: 275-283. IF=7.76
6. ChangYang Gong*, et al. Improving antitumor activity with polymeric micelles entrapping paclitaxel in pulmonary carcinoma. Nanoscale 2012, 4: 6004-6017. IF=7.76
5. ChangYang Gong, et al, Zhiyong Qian*. Improving Intraperitoneal Chemotherapeutic Effect and Preventing Postsurgical Adhesions Simultaneously with Biodegradable Micelles. Nanomed-Nanotechnol 2012, 8(6): 963-973. IF=5.671
4. Na Lei, ChangYang Gong#, et al., Zhiyong Qian*. Therapeutic application of injectable thermosensitive hydrogel in preventinglocal breast cancer recurrence and improving incision wound healing in amouse model. Nanoscale 2012, 4:5686-5693. IF=7.76
3. ChangYang Gong, et al, Zhiyong Qian*. Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites. Nanoscale 2012, 4: 3095-3104. IF=7.76
2. Fang Fang, ChangYang Gong#, et al, Zhiyong Qian*. Honokiol Nanoparticles in Thermosensitive Hydrogel: Therapeutic Effects on Malignant Pleural Effusion. ACS Nano 2009, 3(12): 4080-4088. IF=13.334
1. ChangYang Gong, et al, Zhiyong Qian*. Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: Sol-gel-sol transition and drug delivery behavior. ACTA Biomater 2009, 5(9): 3358-3370. IF=6.008
 
【联系方式】
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邮箱:chygong14@163.com(常用)   gongchangyang@scu.edu.cn
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生物治疗国家重点实验室 管理入口
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