二级导航
招生简章
博士生导师
硕士生导师
培养方案
奖项介绍
研究生会
 
  逯光文

【简历】
逯光文,四川大学生物治疗国家重点实验室教授,教育部“长江学者奖励计划”青年学者项目获得者,国家优秀青年科学基金获得者,入选四川省“千人计划”。
20059-20116 中国科学院微生物研究所博士
20117-20147 中国科学院微生物研究所助理研究员
20148-20152 中国科学院微生物研究所副研究员
20153月至今 四川大学生物治疗国家重点实验室教授
主要从事囊膜病毒的受体识别和致病机制研究。通过解析病原表面配体与宿主受体分子的复合物结构,并进一步利用生物化学、细胞生物学等方法验证结合模式,揭示病原侵入机制,为寻找有效的、靶向病毒侵入过程的抑制剂分子提供基础。目前已在国际学术期刊发表SCI论文27篇,其中以第一或通讯作者(含共第一和共通讯)在NatureNature Structural Molecular BiologyPNASNature Communications等国际杂志发表论文13篇,参与译校《病毒学原理》(第三版)书籍1部,申请国家发明专利2项,主持国家自然科学基金项目3项,作为子课题负责人参加传染病防治重大专项项目1项。曾获得中科院卢嘉锡青年人才奖,中科院卓越青年科学家奖,第一届梅里埃优秀青年科学家奖,“大挑战2015●青年科学家”称号等,并多次受邀在国际和国内病毒学会议中作大会或分会报告。
 
【主要研究方向】
1.        病毒侵入与致病机制研究;
2.        病毒与宿主互作的分子基础研究;
3.        基于结构的疫苗设计和抗体改造。
 
【代表性论著】
1. Guangwen Lu#, Yawei Hu#, Qihui Wang#, Jianxun Qi#, Feng Gao#, Yan Li, Yanfang Zhang, Wei Zhang, Yuan Yuan, Jinku Bao, Buchang Zhang, Yi Shi, Jinghua Yan, George F. Gao*. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 500(7461), pp 227, 2013.
2. Qiong Lu#, Guangwen Lu#, Jianxun Qi, Han Wang, Yifang Xuan, Qihui Wang, Yan Li, Yanfang Zhang, Chunfu Zheng, Zheng Fan, Jinghua Yan, George F. Gao*. Pilrα and pilrβ have a siglec fold and provide the basis of binding to sialic acid. Proceedings of the National Academy of Sciences of the United States of America, 111(22), pp 8221, 2014.
3. Xiaoai Zhang#, Guangwen Lu#, Jianxun Qi, Yan Li, Yan He, Xiang Xu, Jia Shi, Catherine W.-H. Zhang, Jinghua Yan, George F. Gao*. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nature Structural and Molecular Biology, 20(1), pp 67, 2013.
4. Guangwen Lu, Qihui Wang, George F. Gao. Bat-to-human: spike features determine ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV and beyond. Trends in Microbiology, 23(8), pp 468, 2015.
5. Guangwen Lu*, Di Liu. SARS-like virus in the Middle East: A truly bat-related coronavirus causing human diseases. Protein Cell,3(11), pp 803, 2012. (corresponding author)
6. Qiong Lu, Hao Lu, Jianxun Qi, Guangwen Lu*, George F Gao*. An octamer of enolase from Strepotococcus suis. Protein Cell, 3(10), pp 769, 2012. (shared corresponding author)
7. Na Zhang#, Jinhua Yan#, Guangwen Lu#, Zhengfei Guo, Zheng Fan, Jiawei Wang, Yi Shi, Jianxun Qi, George F. Gao*. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications, 2, pp 577, 2011.
8. Guangwen Lu#, Na Zhang#, Jianxun Qi, Yan Li, Zhujun Chen, Chunfu Zheng, George F. Gao, Jinghua Yan*. Crystal structure of Herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. Journal of Virology, 88(23), pp13678, 2014.
9. Guangwen Lu, Jianxun Qi, Zhujun Chen, Xiang Xu, Feng Gao, Daizong Lin, Wangke Qian, Hong Liu, Hualiang Jiang, Jinghua Yan, George F. Gao*. Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. Journal of Virology, 85(19), pp 10319, 2011.
10. Guangwen Lu, Jianxun Qi, Feng Gao, Jinghua Yan, Jiaqi Tang, George F. Gao*. A novel "open-form" structure of sortaseC from Streptococcus suis. Proteins, 79(9), pp 2764, 2011.
11. Guangwen Lu#, Jie Zhang#, Yan Li#, Zhixin Li, Na Zhang, Xiang Xu, Tingting Wang, Zhenhong Guan, George F. Gao, Jinghua Yan*. hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA. Protein Cell, 2(1), pp 64, 2011.
12. Xinsheng Tian#, Guangwen Lu#, Feng Gao, Hao Peng, Youjun Feng, Guangpeng Ma, Mark Bartlam, Kegong Tian, Jinghua Yan, Rolf Hilgenfeld, George F. Gao. Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Journal of Molecular Biology, 392(4), pp 977, 2009.
#: shared first author
 
【联系方式】
电话:13488753418
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041