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  许恒
简历
 
 许恒,四川大学生物治疗国家重点实验室研究员,博士生导师,国家“青年千人计划”学者,国家自然基金委优秀青年。
   2014.9-至今     四川大学华西医院生物治疗国家重点实验室,研究员
   2010.4-2014.7   美国St. Jude 儿童研究医院,博士后
   2004.9-2010.4   中科院上海生命科学院,博士
   2000.9-2004.7   南京大学生命科学院,学士
   主要研究方向为医学遗传学和药物基因组学,任中国药理学协会药物基因组分会常委,中国医药生物技术协会精准医疗分会委员。研究主要以临床—基础—临床的思路,从临床疾病和患者样本入手,对相关的基础生物学实验、生物信息学分析、生物统计学分析,以及基础医学(如药理学)进行交叉学科转化研究。目前已在Nature GeneticsJournal of Clinic OncologyJournal of National Cancer InstituteNature Communications等杂志发表SCI论文22篇(累积影响因子214.6),其中第一作者8篇(累积影响因子99.5)。
 
研究方向与课题:
1. 在基因组水平上寻找影响个体对药物反应差异的遗传学因素,为临床进行精准用药指导;
2. 利用疾病家系或者大样本量的疾病散发人群进行基因组学分析,寻找相关致病基因变异,为预防和治疗疾病提供分子水平基础;
3. 在基因组水平,表观遗传水平等方面寻找肿瘤相关变异,为肿瘤早期检测,相关靶向药物开发等提供候选位点和靶点。
4.. 研究药物相关基因与影响药物反应的机制,确定个体基因组变异与药物的直接关系。
 
联系方式:
 
地址:         四川省成都市人民南路3段17号
四川大学生物治疗国家重点实验室
邮编610041
电话号码:      15928058711
E-mail:        xuheng81916@gmail.comxuheng81916@scu.edu.cn
代表论文
 
1.  H Xu, GW Robinson, J Huang, JY Lim, et al, Common Variants in ACYP2 Influence Susceptibility to Cisplatin-induced Hearing Loss. Nat Genet, 2015. 47(3): p. 263-6.
2.     H Xu, C Cheng, M Devidas, D Pei, et al, ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol, 2012. 30(7): p. 751-7.
3.     H Xu, W Yang, V Perez-Andreu, M Devidas, et al, Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst, 2013. 105(10): p. 733-42.
4.     H Xu, P Wang, Y Fu, Y Zheng, et al, Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts. Cell Res, 2010. 20(4): p. 445-57.
5.   H Xu, H Zhang, Wenjian Yang, et al, Inherited Coding Variants at the CDKN2A Locus Influence Susceptibility to Acute Lymphoblastic Leukemia in Children. Nat Commun, 2015; 6: 7553.  
6.     V Perez-Andreu(#), KG Roberts(#), H Xu(#), C Smith, et al, A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Blood, 2015. 125(4): p. 680-6. (共同一作)
7.     H Xu, P Wang, J You, Y Zheng, Y Fu, Q Tang, L Zhou, Z Wei, B Lin, Y Shu, Y Zhu, L Hu, and X Kong, Screening of Kozak-motif-located SNPs and analysis of their association with human diseases. Biochem Biophys Res Commun, 2010. 392(1): p. 89-94.
8.     H Xu, and JJ Yang, CEBPE promoter SNPs, caught red handed? A commentary on identification of functional nucleotide and haplotype variants in the promoter of the CEBPE gene. J Hum Genet, 2013. 58(9): p. 571-2.
9.     V Perez-Andreu, KG Roberts, RC Harvey, W Yang, C Cheng, D Pei, H Xu, et al, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet, 2013. 45(12): p. 1494-8.
10.  T Moriyama, ML Metzger, G Wu, et al, Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol, 2015, 16(16):1659-66.
11.   V Perez-Andreu, H Xu, and JJ Yang, The novel susceptibility variants for childhood acute lymphoblastic leukemia. J Natl Cancer Inst, 2013. 105(19): p. 1512-3.
12.   Z Zhang, L Zhou, L Hu, Y Zhu, H Xu, et al, Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation. Mol Syst Biol, 2010. 6: p. 442.
13.   X Liu, D Han, J Li, B Han, X Ouyang, J Cheng, X Li, Z Jin, Y Wang, M Bitner-Glindzicz, X Kong, H Xu, et al, Loss-of-function mutations in the PRPS1 gene cause a type of nonsyndromic X-linked sensorineural deafness, DFN2. Am J Hum Genet, 2010. 86(1): p. 65-71.
14.   Z Q Wang, L Si, Q Tang, D Lin, Z Fu, J Zhang, B Cui, Y Zhu, X Kong, M Deng, Y Xia, H Xu, et al, Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation. Am J Hum Genet, 2009. 84(5): p. 672-7.
15.  Z Wei, Y Liu, H Xu, et al, Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations. Sci Rep 2015; 5: 10879.
16.   L Zhou, Z Zhang, Y Zheng, Y Zhu, Z Wei, H Xu, et al, SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell. J Cell Mol Med, 2011. 15(4): p. 783-95.
17.   Y Lu, Y Yu, Z Zhu, H Xu, et al, Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related. Cancer Lett, 2005. 224(2): p. 329-37.1.
 
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041