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  谢永美

谢永美,男,博士,副研究员,硕士生导师。2009年毕业于四川大学制药工程系。长期从事药物设计、合成及活性研究,目前已在国内外学术期刊上发表研究论文50余篇,其中第一作者和通讯作者SCI论文30余篇,包括Journal of Controlled Release, Cell Death&DiseaseNanoscale, Chemical Communications等。申请发明专利17项,其中PCT专利3项,获得授权专利12项。作为项目负责人,承担了国家自然基金青年项目1项(81302639)、中国博士后科学基金2项(20110464420100471652)、四川大学青年科学基金项目12010SCU11033,并有两个一类新药转让给国内医药企业。

 
主要研究方向:
  1. 抗肿瘤药物合成及活性研究
  2. 抗HBV药物合成及活性研究
  3. 抗糖尿病药物合成及活性研究
  4. 化学生物学
 
联系方式:
Tel15882410198
QQ: 158491693
 
代表性论著
2.       Yuqin Yao, Lin Yu, Xiaolan Su, Yuxi Wang, Wenting Li, Yangpin Wu, Xiangzheng Cheng, Hang Zhang, Xian Wei, Hao Chen, Rundong Zhang, Lantu Gou, Xiaoxin Cheng, Yongmei Xie*, Bo Zhang, Yonghui Zhang, Jinliang Yang*, Yuquan Wei. Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates. Journal of Controlled Release, 2015, 220(Pt A): 5-17.
3.       Nannan Zhang, Shichang Liu, Ning Wang, Senyi Deng, Linjiang Song, Qinjie Wu, Lei Liu, Weijun Su, Yuquan Wei, Yongmei Xie*, Changyang Gong*. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale, 2015, 7(6): 2609- 2624.
4.       Yu Liu, Kun Li*, Ming-Yu Wu, Yan-Hong Liu, Yong-Mei Xie*, Xiao-Qi Yu*. A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2 derivatives in living cells. Chemical Communications, 2015, 51(50): 10236-10239.
5.       Fangfang Yang, Yang Yu, Qian Lei, Anqi Zeng, Yali Li, Yongmei Xie*, TingHong Ye*, Yuquan Wei. Lobaplatin arrests cell cycle progression, induces apoptosis and impairs migration and invasion in B16-F10 melanoma cell line in vitro. Biomedicine & Pharmacotherapy, 2015, 69:402–408.
6.       Miao Zhan, Ruixue Xu, Ye Tian, Hongxia Jiang, Lifeng Zhao, Yongmei Xie*, Yuanwei Chen*. A simple and cost-effective method for the regioselective deuteration of phenols. European Journal of Organic Chemistry, 2015, (15): 3370–3373.
7.       JiTing Hou, MingYu Wu, Kun Li*, Jin Yang, KangKang Yu, Yongmei Xie*, XiaoQi Yu*. Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging. Chemical Communications, 2014, 50(63), 8640-8643.
8.       KangKang Yu, Kun Li*, JiTing Hou, Jin Yang,Yongmei Xie*XiaoQi Yu*. Rhodamine based pH-sensitive “intelligent” polymer as lysosome targeting probes and their imaging application in vivo. Polymer Chemistry, 2014, 5(19): 5804-5812.
9.       TianMing Wu, DaoCai Wang, Pu Xiang, JianNan Zhang, YaXiong Sang, HongJun Lin, Jie Chen, Gang Xie, Hang Song, YingLan Zhao*, Yongmei Xie*. Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists. Bioorganic & Medicinal Chemistry Letters, 2014, 24(5): 1426-1431.
10Yuqin Yao, Xiaolan Su, Yongmei Xie*, Yuxi Wang, Tairan Kang, Lantu Gou,Chen Yi, Jinliang Yang*. Synthesis, characterization, and antitumor evaluation of the albumin–SN38 conjugate. Anti-cancer Drugs, 2013,24(3): 270- 277.
 
授权专利
1.       谢永美,魏于全,耿福能.一种治疗糖尿病的化合物.2016.3,中国,专利号: CN201310414045.
2.      谢永美,魏于全,李炯.β-L-2’-脱氧-胸腺嘧啶核苷衍生物及其制备方法和用途,2015.2,中国,专利号:CN201110046505.
3.       谢永美,魏于全,赵瀛兰.信号通路抑制剂及其制备方法和用途. 中国发明专利:2013100171142.
4.       谢永美,魏于全,李炯. 无环核苷酸类似物及其制备方法和应用,2015.1,中国,专利号:CN201210220153.
5.       陈元伟,谢永美,魏于全. 氘代吲哚酮化合物及其制备方法和用途. 2016.3,中国,专利号:201310220973.1.
6.    唐小海,谢永美,宋鑫,邱宇.一种复方紫杉醇-鸦胆子油注射乳剂及其制备方法,2011.7,中国,中国,专利号:CN200810304857.
7.       唐小海,谢永美,宋鑫,邱宇.一种pH敏感型抗癌前药及其制备方法和用途,2010.2,中国,专利号:CN200810306463.
8.    唐小海,邱宇,谢永美,左渊洁,宋鑫.S-奥美拉唑固体分散体及含有该分散体的组合物, 2011.4,中国,专利号:CN200610021687.
9.       唐小海,邱宇,谢永美.一种抗癌前药及其制备方法和用途,2010.4,中国,专利号:CN200510020337.
10.    唐小海,邱宇,宋鑫,谢永美.一种微乳载药系统及制备方法,2013.1,中国,专利号:CN200910301662.
11.    唐小海,邱宇,谢永美,宋鑫.一种抗癌前药及其制备方法和用途,2009.12,中国,专利号:CN200710201724
12.    唐小海,邱宇,谢永美.接枝纳米炭抗癌前药及其制备方法和应用,2009.11,中国,专利号:CN 200510021728  
申请专利
1.    Xie Yongmei, Wei Yuquan, Geng Funeng. Pyrrolopyrimidine Compound and Use Thereof in Preparation of Hypoglaecemic Drug. WO2015078417. 2014-11-28
2.     Xie, Yongmei, Wei, Yuquan, Geng, Funeng. Compound for Treating Diabetes. WO2015027911. 2014-08-27
3.   XIE, Yongmei, WEI, Yuquan, LI, Jiong, GENG, Funeng. Acyclic nucleotide analogue, preparation method therefor, and application thereof. WO2014000541. 2013-05-22
4.       谢永美,魏于全,耿福能. 具有抗糖尿病的吡咯并嘧啶化合物. 中国发明专利:201310633681.0, 申请日:2013.11.29.
5.       谢永美,魏于全,耿福能. 替诺福韦二吡呋酯的制备方法. 中国发明专利:201310270413.7, 申请日:2013.06.29.
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041