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  陈强

 

【简历】

2013-至今    四川大学 生物治疗国家重点实验室          副研究员

2006-2012 哈佛大学医学院 Dana-Farber癌症研究所     博士后

2001-2006 北京大学 生命科学学院            博士

1997-2001 北京大学 生命科学学院            本科

 

2013年回国建立实验室以来,已在Nature, Science Advances, Nature Communications等杂志发表SCI论文12篇。受邀为Cell Research, BMC Genomics, Scientific Reports等杂志审稿。

 

【研究方向】

1、运用X-光晶体学以及其它实验方法研究生物大分子的结构与功能的关系,重点研究参与细胞信号转导的蛋白质分子,尤其是神经发育相关的细胞表面受体。一个长远目标是阐明生物信号跨膜传递的分子机制。

2、基于结构的合理化药物设计,阐明药物的作用机制。

 

【代表性论文】

1.   Niu L, Wang Y, Wang C, Wang Y, Jiang X, Ma L, Wu C, Yu Y#, Chen Q#. Structure of 4′-demethylepipodophyllotoxin in complex with tubulin provides arationale for drug design. Biochem Biophys Res Commun. 2017. Accepted

2.   Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q#, Yang J#. Mechanism of microtubule stabilization by taccalonolide AJ. Nat Commun. 2017 Jun 6;8:15787. doi: 10.1038/ncomms15787.

3.   Yang J, Wang Y, Wang T, Jiang J, Botting CH, Liu H, Chen Q, Yang J, Naismith JH, Zhu X, Chen L. Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule. Nat Commun. 2016 Jun 30;7:12103. doi: 10.1038/ncomms12103.

4.   Li SA, Cheng L, Yu Y#, Chen Q#. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition. Sci Adv. 2016 May 27; 2(5):e1501118. doi: 10.1126/sciadv.1501118. eCollection 2016 May.

5.   Wang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, Lai Q, Yang Z, Chen Q#, Yang J#. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. FEBS J. 2016 Jan;283(1):102-11. doi: 10.1111/febs.13555. Epub 2015 Nov 4.

6.   Wu CY, Liang MX, Chen Q#. Production and stabilization of an integrin-binding moiety of complement component 3. Mol Biol (Mosk). 2015 Sep-Oct;49(5):811-6. doi: 10.7868/S0026898415050201.

7.   Cheng L, Li SA, Yu Y#, Chen Q#. Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1. Acta Crystallogr F Struct Biol Commun. 2015 Jun 1;71(Pt 6):775-8.

8.   Li SA, Cheng L, Yu Y#, Chen Q#. Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain. Acta Crystallogr F Struct Biol Commun. 2015 Mar 1;71(Pt 3):330-2. doi: 10.1107/S2053230X15002897. Epub 2015 Feb 19.

9.   Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848.

10. Chen Q, Sun X, Zhou XH, Liu JH, Wu J, Zhang Y, Wang JH#. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J Cell Sci. 2013; 126(Pt 1):186-95.

11. Schürpf T*, Chen Q*, Liu JH, Wang R, Springer TA, Wang JH#. The RGD finger of Del-1 is a unique structural feature critical for integrin binding. FASEB J. 2012; 26(8):3412-20.

12. Chen Q, You D, Liang Y, Su X, Gu X, Luo M, Zheng X. Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant - insights into inhibitor design. FEBS J. 2007; 274(17): 4408-4415.

13. Zheng X, Dai X, Zhao Y, Chen Q, Lu F, Yao D, Yu Q, Liu X, Zhang C, Gu X, Luo M. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc Natl Acad Sci U S A. 2007; 104(21): 8809-14.

14. Chen Q, Hui RT, Sun CH, Gu XC, Luo M, Zheng XF#. Soluble expression, purification and stabilization of a pro-apoptotic human protein, CARP. Protein Expr Purif. 2006; 45:329-34.

15. Chen Q, Liang YH, Su XD, Gu XC, Zheng XF, Luo M. Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis. J Mol Biol. 2005; 249:1199-1210.

16. Chen Q, You D, Hu MH, Gu X, Luo M, Lu SY. Cloning, purification and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis. Protein Expr Purif. 2003; 32:239-245.

 

* Co-first author

# 通讯作者

被 “Faculty of 1000”推荐

 

受邀报告

1、《Netrin Receptors in Axon Guidance Zhejiang University (2016)

2、 《Structural View of Netrin Receptors in Axon GuidanceThe 4th International Conference on Nucleic Acid-Protein Chemistry and Structural Biology for Drug Discovery (2014)

 

【联系方式】  

 

e-mail      qiang_chen@scu.edu.cn

 

生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041