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  米鹏

米 鹏

 

国家重点研发计划,纳米科技青年项目首席科学家

四川大学生物治疗国家重点实验室特聘研究员

四川省卫计委学术技术带头人

 

NOTE: 本课题组常年招收化学, 药学, 高分子及制药工程方向博士后, 待遇优厚, 联系方式: mi@scu.edu.cn.

 

简历:

2016           四川大学生物治疗国家重点实验室,华西医院放射科双聘

20152016    主任研究员(PI), 日本纳米药物创新中心(iCONM, 川崎)

20132015    日本学术振兴会(JSPS)外国人特别研究员(Nobuhiro Nishiyama 教授合作)

2017            客座研究员, 日本纳米药物创新中心(iCONM, 川崎)

20132015    客座研究员, 东京大学医学院研究科附属疾患生命技术中心

20162017    客座研究员, 东京大学工学系研究科

20152016    客座研究员, 东京工业大学资源化学研究所高分子材料部门

20092013    东京大学, 生物工程系,博士 (导师:Kazunori Kataoka 教授)

20052008    四川大学, 制药与生物工程系,硕士 (导师:褚良银 教授)

20012005    四川大学, 制药工程, 本科,保送研究生

 

主要研究方向:

生物医药材料:化学合成和制备一系列具有高附加值,可降解的生物材料,应用于药物的控制释放,组织工程,疾病诊断等领域。

疾病的早期与精准诊断:构建高灵敏度和高选择性的诊断试剂实现对疾病的无创体外精准诊断;构建新型分子探针来提高临床上分子影像手段的的检测精度和灵敏度, 实现对疾病的快速,早期和精准的诊断,疾病的机理研究,以及管理和反馈预后效果。

新型靶向纳米药物:构建新型纳米药物实现对病灶的靶向和智能化药物控制释放,实现对癌症等重大疾病的化学治疗,RNAi,基因治疗,免疫治疗及放射治疗等多模式治疗和协同治疗等个性化治疗方案。

 

[1]  Mi P, Kokuryo D, Cabral H, Wu H, Terada Y, Saga T, Aoki I*, Nishiyama N*, Kataoka K*. A pH-activatable nanoparticle with signal amplification capabilities for non-invasive imaging of tumour malignancy. Nat Nanotechnol. 2016, 11(8), 724-730.

[2]  Mi P *, Yanagie H, Dewi N, Yen H, Liu X, Suzuki M, Sakurai Y, Ono K, Takahashi H, Cabral H*, Kataoka K*, Nishiyama N*. Boron cluster-carrying polymeric constructs for effective boron neutron capture therapy of solid tumors. J Control Release. 2017, 254: 1-9.

[3]  Quader S, Liu X, Chen Y, Mi P, Chida T, Ishii T, Miura Y, Nishiyama N, Cabral H, Kataoka K*. cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J Control Release. 2017, 258: 56-66.

[4]  Mi P*, Cabral H, Aoki I, Nishiyama N, Kataoka K*, A nanoparticle with pH-triggered contrast amplification ability for tumor malignancy imaging. J Control Release. 2017, 259: e102. DOI: 10.1016/j.jconrel.2017.03.216

[5]  Mi P#, Wang F#, Nishiyama N, Cabral H*. Molecular Cancer Imaging with Polymeric Nanoassemblies: From Tumor Detection to Theranostics. Macromol Biosci. 2017, 17(1): 1600305. (Cover Story)

[6]  Zeng Y, Wang L, Zhou Z, Wang X, Zhang Y, Wang J, Mi P*, Liu G*, Zhou L*, Gadolinium hybrid iron oxide nanocomposites for dual T1- and T2-weighted MR imaging of cell labeling. Biomaterials Science. 2017, 5: 50-56.

[7]  Wang J#, Mi P#, Lin G#, Wang Y*, Liu G*, Chen X*. Molecular imaging guided delivery of RNAi therapeutics for cancer. Adv Drug Deliver Rev. 2016, 104, 44-60.

[8]  Yi Y, Kim HJ, Mi P, Zheng M, Takemoto H, Toh K, Kim BS, Hayashi K, Naito M, Matsumoto Y, Miyata K, Kataoka K. Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J Control Release. 2016, 244: 247-256.

[9]  Mi P, Zhang P, Liu G*. Bio-inspired virus-like nanovesicle for effective vaccination. Human Vaccines & Immunotherapeutics. 2016, 4: 1-2.

[10]     Lin G#, Mi P#, Chu C, Zhang J, Liu G*. Inorganic Nanocarriers overcoming multidrug resistance for cancer theranostics. Adv Sci. 2016, 3(11): 1600134..

[11]     Perche F, Yi Y, Hespel L, Mi P, Cabral H, Dirisala A, Miyata K, Kataoka K*.  Hydroxychloroquine-conjugated Gold Nanoparticles for Improved siRNA Activity. Biomaterials. 2016, 90: 62-71.

[12]     He C, Jiang S, Jin H, Chen S, Lin G, Yao H, Wang X, Mi P, Ji Z, Lin Y, Lin Z, Liu G*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016, 83: 102-114.

[13]     Mi P, Dewi N, Yanagie H, Kokuryo D, Suzuki M, Sakurai Y, Li Y, Aoki I, Ono K, Takahashi H, Cabral H, Nishiyama N*, Kataoka K*. Hybrid micelles incorporating gadolinium chelates for imaging-guided neutron capture tumor therapy. ACS Nano. 2015, 9 (6): 5913-5921.

[14]     Mi P, Yanagie H, Kokuryo D, Dewi N, Aoki I, Nishiyama N*, Kataoka K*. Block copolymer hybrid calcium phosphate micelles for cancer diagnosis and neutron capture therapy. J Control Release. 2015, 213 (28): e88. DOI: 10.1016/j.jconrel.2015.05.146

[15]     Cabral H, Makino J, Matsumoto Y, Mi P, Wu H, Nomoto T, Toh K, Yamada N, Higuchi Y, Konishi S, Kano MR, Nishihara H, Miura Y, Nishiyama N, Kataoka K*. Systemic targeting of lymph node metastasis through blood vascular system by using size-controlled nanocarriers. ACS Nano. 2015, 9(5): 4957-4967.

[16]     Mi P, Kokuryo D, Cabral H, Kumagai M, Nomoto T, Aoki I, Terada Y, Kishimura A, Nishiyama N*, Kataoka K*. Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. J Control Release. 2014, 174 (28): 63-71.

[17]     Chen H#, Xiao L#, Anraku Y, Mi P, Liu X, Cabral H, Inoue A, Nomoto T, Kishimura A*, Nishiyama N*, Kataoka K*. Polyion complex vesicles for photoinduced intracellular delivery of amphiphilic photosensitizer. JACS. 2014, 136 (1) 157-163.

[18]     Yen H, Cabral H, Mi P, Toh K, Liu X, Koori H, Kim A, Miyazaki K, Miura Y, Nishiyama N, Kataoka K*. Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano. 2014, 8(11): 11591-11602.

[19]     Kim HJ, Takemoto H, Yi Y, Zheng M, Maeda Y, Chaya H, Hayashi K, Mi P, Pittella F, Christie RJ, Toh K, Matsumoto Y, N. Nishiyama N, Miyata K*, Kataoka K*. Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano. 2014, 8(9): 8979-8991.

[20]     Wu H, Cabral H, Toh K, Mi P, Chen Y, Matsumoto Y, Yamada N, Liu X, Kinoh H, Miura Y, Kano MR, Nishihara H, Nishiyama N, Kataoka K*. Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation. J Control Release. 2014, 189: 1-10.

[21]     Pittella F, Cabral H, Maeda Y, Mi P, Watanabe S, Kim HJ, Nishiyama N, Miyata K*, Kataoka K*. Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J Control Release. 2014, 178 (32): 18-24.

[22]     Mi P, Cabral H, Kokuryo D, Rafi M, Terada Y, Aoki I, Saga T, Takehiko I, Nishiyama N, Kataoka K*. Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging. Biomaterials. 2013, 34(2): 492-500.

[23]     Rafi M, Cabral H, Kano MR, Mi P, Iwata C, Yashiro M, Hirakawa K, Miyazono K, Nishiyama N, Kataoka K*. Polymeric micelles incorporating (1,2-diaminocyclohexane) platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. J Control Release. 2012, 159(2): 189-196.

[24]     Mi P, Ju X, Xie R, Wu H, Ma J, Chu L*. A novel stimuli-responsive hydrogel for K+-induced controlled-release. Polymer. 2010, 51(7): 1648-1653.

[25]     Mi P, Chu L*, Ju X, Niu C.H. A smart polymer with ion-induced negative shift of the lower critical solution temperature for phase-transition. Macromolecular Rapid Communication. 2008, 29(1): 27-32 (Cover story, ranked No.12 the Most-Accessed Articles in 01/2008)

[26]     Ju X, Chu L*, Liu L, Mi P, Lee YM. A novel thermo-responsive hydrogel with ion-recognition property through supramolecular host-guest complexation. The Journal of Physical Chemistry B. 2008, 112(4): 1112-1118.

[27]     Ju X, Chu L*, Liu L, Mi P, Song H, Lee YM. Synthesis and characterization of a novel thermo-sensitive copolymer of N-isopropylacrylamide and dibenzo-18-crown-6-diacrylamide. Macromolecular Rapid Communication. 2006, 27, 2072-2077. (Front Cover, ranked No.6 and No.9 the Most-Accessed Articles in Dec. 2006 and Jan. 2007 respectively)

 

联系方式:

四川省成都市人民南路317号四川大学生物治国家重点实验室,邮编610041 

 

电子邮件:mi@scu.edu.cn

生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041