二级导航
招生简章
博士生导师
硕士生导师
培养方案
奖项介绍
研究生会
 
  邓洪新

 

(一)个人简介:
    邓洪新,男,1974年12月出生,博士,2010年12月被破格聘为肿瘤学博士研究生导师, 2014年7月被评为研究员,四川大学华西医院生物治疗国家重点实验室学术带头人。2011年度教育部新世纪优秀人才基金获得者,2011年度四川省杰出青年学术技术带头人资助计划基金获得者,第十批四川省学术技术带头人后备人选。2001年7月至今,主要从事肿瘤微环境及肿瘤的免疫基因治疗研究、干细胞治疗的基础与临床转化研究。近几年来,作为课题负责人承担了国家“重大新药创制”重大科技专项、国家“863”重点课题子课题、国家“973”子课题、国家自然科学基金、教育部新世纪优秀人才基金、四川省杰出青年科学基金、四川省科技攻关等项目10余项。共合作发表SCI论文90多篇,其中第一作者或通讯作者发表在Nature Communications(IF=11.329), Clin Cancer Res (IF=8.738), Small(IF=8.315),J Immunol. Sci Rep, J Cell Mol Med, Hum Gene Thera, Stem Cell Res Thera.等SCI收录的杂志上发表论文48篇,申请国家发明专利15项,获得授权发明专利7项。
(二)任职任编:
    中国医药生物技术协会再生医学分会常务委员,中国免疫学会青年工作者委员会常务委员,中国转化医学联盟理事,中国医药生物技术协会转化医学分会委员,中国医药生物技术协会基因治疗分会委员,四川省免疫学会常务理事,四川省免疫学会肿瘤免疫专业委员会第一届主任委员,四川省实验动物学会常务理事。Clin Cancer ResHuman Gene TherapyMolecular Cancer TherapeuticsInt J Cancer等杂志特邀审稿人。
(三)主要研究方向
    主要从事肿瘤相关的新基因功能研究,肿瘤抗血管生成治疗研究,肿瘤免疫微环境研究,肿瘤免疫基因治疗研究以及干细胞定向诱导分化研究,干细胞治疗等相关的基础研究及生物技术药物研发工作。
(四)招生专业
招收细胞生物学专业、人类重大疾病的生物治疗专业、生物化学与分子生物学专业、生物与医药专业的硕士和博士研究生。
(五)博士后招生
     博士后招生单位挂靠在华西医院,常年招收细胞生物学专业、人类重大疾病的生物治疗专业、生物化学与分子生物学专业、生物与医药等专业的博士后,一年可多次进站,入站的博士后一般3年,年薪17万元以上,读博士后期间优秀的可以评为是四川大学副研究员。欢迎优秀博士毕业生来开展高水平的合作研究。
(六)近几年发表的代表性论文
1.        Lei Dai, Xueliang Cui, Xin Zhang, Lin Cheng, Yi Liu, Yang Yang, Ping Fan, Qingnan Wang, Yi Lin, Junfeng Zhang, Chunlei Li, Ying Mao, Qin Wang,Xiaolan Su, Shuang Zhang,Yong Peng, Hanshuo Yang, Xun Hu, Jinliang Yang, Meijuan Huang, Rong Xiang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng*. SARI inhibits angiogenesis and tumor growth of human colon cancer through directly targeting ceruloplasmin Nature Communications. 2016. Jun 29;7:11996. doi: 10.1038/ ncomms11996.(通讯作者)
2.        Fen Xu, Tianyi Kang, Jie Deng, Junli Liu, Liang Ouyang, Xiaolei Chen, Yuan Wang, Ting Du, Hong Tang, Xiaoping Xu, Shaochen Chen, Yanan Du, Zhiyong Qian, Yuquan Wei, Hongxin Deng* and Maling Gou*. Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification Small. 2016 Apr;12(15):2067-76   (通讯作者)
3.     Junfeng Zhang, Yi Lin, Chunlei Li, Xiaomei Zhang, Lin Cheng, Lei Dai, Youcui Wang, Fangfang Wang,Gang Shi, Xueliang Cui, Yi Liu, Qianmei Yang, HuiLing Wang, Shuang Zhang, Yang Yang, Rong Xiang, Jiong Li, Dechao Yu, Yuquan Wei, Hongxin Deng*. IL-35 decelerates the inflammatory process by regulating inflammatory cytokine secretion and M1/M2 macrophages ratio in psoriasis. J Immunol. 2016.197: 2131-2144.(通讯作者)
4.        Yanli Fu, Jie Deng, Qinyuan Jiang,Yuan Wang, Yujing Zhang, Yunqi Yao, Fuyi Cheng, XiaoLei Chen, Fen Xu, Meijuan Huang, Yang Yang, Zhang Shuang, Dechao Yu, Robert Chunhua Zhao, Yuquan Weiand Hongxin Deng*.Rapid Generation of Functional Hepatocyte-like Cells from Human Adipose-Derived Stem Cells. 2016. Stem Cell Res. Thera. 2016,7:105 DOI 10.1186/ s13287-016-0364-6 (通讯作者)
5.        Hongwei Tian, Gang Shi, Qin Wang, Yiming Li, Qianmei Yang, Chunlei Li,Guoyou Yang, Min Wu, Qian Xie, Shuang Zhang, Yang Yang, Rong Xiang, Dechao Yu, Yuquan Wei, Hongxin Deng*. A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.Signal Transduction and Targeted Therapy.2016.in press. (通讯作者)
6.        Xiao-mei Zhang,Yu-jing Zhang,Wei Wang, Yu-quan Wei and Hong-xin Deng*. Stem Cell Treatment in Crohn’s Disease.Hum. Gene Thera.2016.in press (通讯作者)
7.        Fen Xu, Junli Liu, Jie Deng, Xiaolei Chen, Yuan Wang, Pengchao Xu, Lin Cheng, Yanli Fu, Fuyi Cheng, Yunqi Yao, Yujing Zhang, Meijuan Huang, Dechao Yu, Yuquan Wei, and Hongxin Deng*. Rapid and High-Efficiency Generation of Mature Functional Hepatocyte-like Cells from Adipose-Derived Stem Cells by a Three-Step Protocol. Stem Cell Res. Thera. 2015 Oct 5;6:193. doi: 10.1186/s13287-015-0181-3通讯作者)
8.        Yu Liu, Guoyou Yang, Junfeng Zhang, Kaiyan Xing, Lei Dai, Lin Cheng, Junli Liu, Jie Deng, Gang Shi , Chunlei Li, Xiaolan Su, Shuang Zhang, Yang Yang, Jia Li, Dechao Yu, Rong Xiang, Yuquan Wei, Hongxin Deng*. Anti-TNF-α monoclonal antibody reverses psoriasis through dual inhibition of inflammation and angiogenesis. Int. Immunopharmacol.. 2015,28:731-743. (通讯作者)
9.        Shuang Zhang*, Min Yu*, Hongxin Deng*, Guobo Shen,Yuquan Wei. Polyclonal rabbit anti-human ovarian cancer globulins inhibit tumor growth through apoptosis involving the caspase signaling. Scientific Reports.2014  May 15;4:4984. doi: 10.1038/srep04984. (并列第一作者)
10.    Hongwei Tian, Gang Shi,Guoyou Yang,Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng*.Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF andIL-18 can induce significant antitumor effects. BMC Cancer.  2014 Jan 29;14:48. doi: 10.1186/ 1471- 2407-14-48. (通讯作者)
11.    Du T, Shi G, Li YM, Zhang JF, Tian HW, Wei YQ, Deng H*, Yu DC*.Tumor-specific Oncolytic Adenoviruses Expressing Granulocyte Macrophage Colony-Stimulating Factor or Anti-CTLA4 Antibody for the Treatment of Cancers. Cancer Gene Thera. 2014; 21(8):340-8 (通讯作者)
12.    Junfeng Zhang, Hongwei Tian, Can Li, Shuang Zhang, Lin Cheng, Xiaomei Zhang, Ruibo Wang, Fen Xu, Lei Dai, Gang Shi, Xiaolei Chen, Yiming Li, Tao Du, Jie Deng, Yu Liu, Yang Yang, Yuquan Wei, Hongxin Deng*. Antitumor effects obtained by autologous Lewis lung cancer cell vaccine engineered to secrete mouse Interleukin 27 by means of cationic liposome. Mol. Immunol.. 2013; 55(3-4):264-74 (通讯作者)
13.    Can Li, Xiaomei Zhang, Yang Yang, Lin Cheng, Lei Dai, Fen Xu, Junfeng Zhang, Hongwei Tian, Xiaolei Chen, Gang Shi, Yiming Li, Tao Du, Shuang Zhang, Yuquan Wei, Hongxin Deng*. RNA interference targeting human FAK and EGFR suppresses human non-small cell lung cancer xenograft growth in nude mice. Cancer Gene Thera. , 2013;20(2):101-8 (通讯作者)
14.    Hongwei Tian, Shengyong Liu, Jungfeng Zhang, Shuang Zhang, Lin Cheng, Xiao-mei Zhang, Can Li, Rui-bo Wang, Lei Dai, Nv Yan, Ping Fan, Li-xia Dai, Yuquan Wei, and Hong-xin Deng*. Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery an plasmid expressing small hairpin RNA targeting Survivin. J. Biomed. Nanotechnol.. 2012. 8(4): 633-641 (通讯作者)
15.    Na Zhang, Yang Yang, Lin Cheng, Xiao-mei Zhang, Shuang Zhang, WeiWang, Sheng-yong Liu, Shu-ya Wang, Rui-bo Wang, Wen-jing Xu, Lei Dai, NvYan, Ping Fan, Li-xia Dai, Hong-wei Tian, Lei Liu, and Hong-xin Deng*. Combination of Caspy2 and IP-10 gene therapy significantly improves therapeutic efficacy against murine malignant neoplasms growth and metastasis. Hum. Gene Thera. 2012, 23(8):837-46 (通讯作者)
16.    Yan, Nv; Zhang, Shuang; Yang, Yang; Cheng, Lin; Li, Can; Dai, Lixia; Dai, Lei; Zhang, Xiaomei; Fan, Ping; Tian, Hongwei; Wang, Ruibo; Chen, Xiaolei; Su, Xiaolan; Li, Yiming; Zhang, Junfeng; Du, Tao; Wei, Yu-quan; Deng, Hong-xin*. Therapeutic upregulation of SCARA5 inhibits tumor growth and metastasis.Cancer Sci. 2012;103(9):1631-9 (通讯作者)
17.    Hong-xin Deng#*, Qing-yuan Jiang#, Yang Yang, Shuang Zhang, Yong-ping Ma, Gang Xie, Xiang Chen, Zhi-yong Qian, Yan-jun Wen, Jiong Li, Jin-liang Yang, Yu Jiang, Xia Zhao, and Yu-quan Wei. Intravenous liposomal delivery of the short hairpin RNAs against Plk1 controls the growth of established human hepatocellular carcinoma. Cancer Biol. Ther..2011. 11(4):401-9. (第一作者,通讯作者)
18.    Shuang Zhang, Zhixing Cao, HongWei Tian, Guobo Shen, Yongping Ma, Huanzhang Xie, Yalin Liu, Chengjian Zhao, Senyi Deng, YangYang, Renlin Zheng, Weiwei Li, Na Zhang, Shengyong Liu, WeiWang, Lixia Dai, Shuai Shi, Lin Cheng, Youli Pan, Shan Feng, XiaZhao, Hongxin Deng*, Shengyong Yang, Yuquan Wei. SKLB1002, A Novel Potent Inhibitor of Vascular Endothelial Growth Factor Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth in Vivo. Clin. Cancer Res.2011,17(13); 4439–50.(通讯作者)
19.    Yang Wan, Anliang Huang, Yang Yang, Gang Xie, Xiang Chen, Jia Hu, Xiancheng Chen, Li Yang, Jiong Li, Lijuan Chen, Yu Jiang, Xia Zhao, Yuquan Wei, Hong-Xin Deng*. A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth. Int. J. Oncol.. 2010, 36: 1121-1128 (通讯作者)
20.    An-liang Huang, Yang Wan, Dian-ying Liao, Huo-zhen Hu, Lin Wei, Xian-huo Wang, Yan-jun Wen, Jiong Li, Li-juan Chen, Bing Kan, Ping Chen, Yong-sheng Wang, Xiang Chen, Xia Zhao, Hong-xin Deng, Yu-quan Wei. Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase.J Cancer Res Clin Oncol. 2010. 136(8):1229-42  (通讯作者)
21.    Fei Yan, Xu-zhi Ruan, Han-shuo Yang, Shao-hua Yao, Xin-yu Zhao, Lan-tu Gou, Fan-xin Ma, Zhu Yuan, Hong-xin Deng*, Yu-quan Wei. Identification, characterization and effects of Xenopus laevis PNAS-4 gene on embryonic development. J. Biomed. Biotechnol. 2010. (通讯作者)
22.    Ke Lei, Lu Ye, Yang Yang, Guan-Jie Wang, Qingyuan Jiang, Yu Jiang, Yu-Quan Wei, and Hong-Xin Deng*. RNA interference-mediated silencing of Focal Adhesion Kinase inhibits growth of human Colon Carcinoma xenograft in nude mice. J. Biomed. Nanotechnol.. 2010. 6(3)272–278 (通讯作者)
23.    Yong P Ma, Yang Yang, Shuang Zhang, Xiang Chen, Na Zhang, Wei Wang, Zhi XCao, Yu Jiang, Xia Zhao and Hong X Deng*. Efficient Inhibition of lung cancer in murine model by plasmid-encoding VEGF short hairpin RNA in combination with low-dose cisplatin. J. Exp. Clin. Cancer. Res. 2010.29,56 (通讯作者)
24.    Liu L, Deng H, Wang Y, Chen P, Yang Y, Yang H, Chen X, Chen L, Zhu W, Liang S, Yang J, Qian Z, Li J, Wen Y, Kan B, Mao Y, Zhao X, Wei Y. A novel strategy for tumor therapy combining cell apoptosis and active immunity induced by caspy2, a zebrafish caspase. J. Cell. Mol. Med.. 2009,13(8B):2271-2281 (并列第一作者,通讯作者)
25.    Dan Su*, HongXin Deng*, Xia Zhao, Xi Zhang, LiJuan Chen, XianCheng Chen, ZhengYu Li, Yu Bai, YongSheng Wang, Qian Zhong, Tao Yi, Yuquan Wei. Targeting CD24 for Treatment of Ovarian Cancer by Short Hairpin RNA. Cytotherapy. 2009. 11(5): 642-52 (并列第一作者)
 
欢迎热爱科研、主动学习能力强、勤奋、踏实、善于思考、能够坚持的学生报考。欢迎医学、细胞生物学、分子生物学、生物技术、生物化学、药学、农学、生物制药工程等方向的学生报考。欢迎校内外保送研究生,接受校内外优秀本科生提前进实验室进行科研训练。
 
    联系方式: 联系电话:18980601960;e-mail: denghongxin01@163.com
    地址:成都高新区高朋大道科园四路 1 号四川大学华西科技园   邮编610041
 
生物治疗国家重点实验室 管理入口
地址:中国四川成都高朋大道科园四路一号 邮编:610041